PPAR isotypes

Domain N-Terminal A/B DNA-Binding Hinge Ligand-Binding 

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The tissue-specific patterns of expression of the PPAR. isotypes suggested that these proteins have distinct physiological roles, and this was further supported when each was specifically disrupted in mouse gene knockout models. 

The expression of all three PPAR isotypes peaks in the rat central nervous system between days 13.5-18.5 of gestation, and while expression of both PPARa and PPARy decline post-natally, expression of PPARS remains high (except for the retina, where all three isoforms are expressed in the adult rodent). An important role for PPARS in CNS development is underscored by the occurrence of defective myelination in the PPARS-null mouse. 

Epidermal Maturation and Wound Healing. All three PPAR isotypes are expressed during epidermal maturation each isotype has a specific pattern of expression in regard to development and the various layers of the epidermis. An important role for PPARS in the development and/or maintenance of normal skin health is indicated by the presence of defective wound healing in the PPARS-null mouse. 

Table 4 summarizes the physiological functions of the PPAR isotypes and their synthetic ligands. 

PPAR isotype Tissues of highest expression Primary physiological effects Endogenous ligands Synthetic ligands Associated disease state/ indication... 

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