Scurvy Wound healing

C Ascorbic acid Coenzyme in hydroxylation of proline and lysine in collagen synthesis antioxidant enhances absorption of iron Scurvy—impaired wound healing, loss of dental cement, subcutaneous hemorrhage... 

Deficiency symptoms In vitamin C deficiency scurvy develops. It is characterized by ecchymosis, petechiae, swollen and bleeding gums, subperiosteal haemorrhage, bones are painful to touch, impaired wound healing, anaemia, loosening of teeth and gingivitis. 

Scurvy Sore, spongy gums Loose teeth Poor wound healing None Benefits of supplementation not established in controlled trials... 

Vitamin C (ascorbic acid) functions as an antioxidant and as a cofactor for hydroxyla tion reactions in procollagen. A deficiency of vitamin C results in scurvy, a disease char acterized by sore, spongy gums, loose teeth, and poor wound healing. There is no known toxicity for this vitamin. 

Ascorbic acid is synthesized by plants and many ani- mals but not by primates or guinea pigs. In scurvy, the disease associated with a severe deficiency of ascorbic acid, connective tissues throughout the body deteriorate. Weakening of the capillary walls results in hemorrhages, wounds heal poorly, and lesions occur in the bones. 

The richest sources of vitamin C are citrus fruits (e.g., lemon, oranges), tomatoes, potatoes, green chilies, and human milk. Severe deficiency causes scurvy and is prevalent in malnourished infants, children, adults, alcoholics, and drug addicts. Symptoms such as bleeding gums, deformed teeth, brittle bones, impaired wound healing, anemia, and growth retardation are observed. 

Deficiency in vitamin C leads to the disease scurvy due to the role of the vitamin in the post-translational modification of collagens. Scurvy is characterized by easily bruised skin, muscle fatigue, soft swollen gums, decreased wound healing and hemorrhaging, osteoporosis, and anemia. Vitamin C is readily absorbed and so the primary cause of vitamin C deficiency is poor diet and/or an increased requirement. The primary physiological state leading to an ihcreased requirement for vitamin C is severe stress (or trauma). This is due to a rapid depletion in the adrenal stores of the vitamin. The reason for the decrease in adrenal vitamin C levels is unclear but may be due either to redistribution of the vitamin to areas that need it or an overall increased utilization. 

Prevents and treats C deficiency (scurvy) increases wound healing for bums sickle cell crisis deep vein thrombosis. Megavitamin therapy (massive doses) of vitamins is not recommended it can cause toxicity. 

Scurvy Decreased Poor wound healing deficient growth fragile capillaries... 

Ascorbic acid, a water-soluble vitamin (1(X) to 250 mg p.o. daily), is indicated in the treatment of frank and subclinical scurvy in extensive bums, delayed fracture or wound healing, postoperative wound healing severe febrile or chronic disease states and in prevention of ascorbic acid deficiency in those with poor nutritional habits or increased requirements. In addition, ascorbic acid has been used for potentiation of meth-enamine in urine acidification and as an adjunctive therapy in the treatment of idiopathic methemoglobinemia. 

A deficiency of vitamin C leads to scurvy, a disorder that is characterized by bleeding gums, loss of teeth, sore joints, and slow wound healing. 

Ross, R.. and Benditt, E. P. Wound healing and collagen formation. IV. Distortion of ribosomal patterns of fibroblasts in scurvy. J. Cell Biol., 304 22 365-389,1964. 

Symptoms of deficiency. Scurvy fatigue, bleeding gums, muscle pain, depression, dry skin, impaired iron absorption, impaired folate metabolism, impaired wound healing. 

Deficiency Impaired synthesis of collagen leads to scurvy characterised by bleeding gums, bruising and poor wound-healing. 

The typical injury of scurvy consists of an incapacity of the mesenchymal cells—such as fibroblasts, osteoblasts, or odontoblasts—to produce their normal fundamental substance. In other words, the cell can proliferate, but it cannot form collagen, osteoid, or dentin. This basic alteration is responsible for increased fragility of the capillaries, retarded wound healing, abnormal bone growth, and eventually abnormal tooth growth [78]. 

Mussini, E., Hutton Jr., J. J., and Udenfriend, S., 1967, Collagen proline hydroxylase in wound healing, granuloma formation, scurvy, and growth. Science 157 927-929. 

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