Activity fungicide

A few commercial applications of benzofuroxans have been suggested in the Patent literature and elsewhere. A wide range of biological activity (fungicidal or fungistatic,bactericidal,i -parasiticidal,i3i and insecticidaP i i jj s been claimed for... 

It has been observed that quite generally the toxic effects of organometallic compounds are stronger than those of the underlying metal ions. This is particularly true for the antimicrobial effects. The metal tin shows this phenomenon in a rather dramatic way. Whereas scarcely any pronounced biological effect is known for tin, either in the stannous or the stannic form, certain trialkyltin compounds belong to the most active fungicides known at present. 

Of the 3-hydroxy-isoxazoles, hymexazole (72) has proved the most active fungicide. For an antifungal action substitution in position 5 is indispensable. The... 

Sodium azide and potassium azide have a broad range of biocidal action, possessing, besides herbicidal activity, fungicidal, bactericidal, nematocidal and insecticidal activity. 

Carboxin is the one of the oldest members of the carboxanilide fungicide family and has been used as an important seed treatment fungicide for about 40 years. A new and more active fungicide, penthiopyrad, with the same mode of action as carboxin, has been discovered where its antifungal spectrum is much broader. 

Ipomeamarone. Formula see ipomeanin. C,5H220], Mr 250.34, [aJi> +27 (C2H5OH), a phytoalexin of the class of furan sesquiterpenes. I. was first isolated from sweet potatoes (Ipomoea batatas) afflicted by black rot. liie amount of I. reaches ca. 2 weight-% of the plant after a short time, it then acts as a highly active fungicide. ... 

Flucytosine 4.23) (5-fluorocytosine, Ancobon ) has proved clinically successful as an orally active fungicide for treating such systemic diseases as candidosis and cryptococcal meningitis (Bennett, 1977). Its selectivity depends on the fact that mammals secrete it unchanged (just as they do cytosine), whereas fungi convert it to 5-fluorouracil and then elaborate this to its cytostatic nucleotide. 

The point of attack of trialkyltin salts (RaSn" ), which are highly active fungicides, is believed to lie in the oxidative phosphorylation of mitochondria (Aldridge, 1958). The tributyl homologue is the most used because it is the least toxic for mammals. 

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