Wound healing model

Human Organ Culture Wound Healing Model... 

Induced models Porcine wound healing models [38]... 

Newton, P., Watson, J., Wolowacz, R., Wood, E., 2004. Macrophages restrain contraction of an in vitro wound healing model. Inflammation 28, 207-214. 

Wound healing Schizophrenia (mouse knockout model) ... 

The model concerning wound healing occurs in two phases (1) pro-inflammatory responses (Glaser and Kiecolt-Glaser 2005 Moore 1999 Tidball 2005 Whelan et al. 2005) which are needed to ensure adequate clearance of pathogen at the site of tissue injury, as well as, (2) re-epithelialization and neovascularization events (Frantz et al. 2005 Moore 1999 Naldini and Carraro 2005 Olah and Caldwell 2003 Whelan et al. 2005) to ensure proper wound closure. It is important to note that the resolution of pathogen clearance is essential in order for the wound closure processes to take place (Robson 1997). 

Consumption of fish oil in excess can generate immunotoxic effects in laboratory animals. Rats fed a 17% fish oil diet had reduced wound-healing responses when compared to com oil [59], In a mouse model of bacterial resistance to S. typhimurium, lower survival rates were reported for those animals that ingested a 20% fish oil diet over 15 days [59], Similar fish oil-induced effects in guinea pigs were noted in a study of experimental tuberculosis leading the authors to conclude that this treatment resulted in decreased resistance to infectious disease. The consumption of fish oil has also been reported to result in alterations of hemostatic parameters such as platelet production and function. However, there is no indication that at doses normally consumed by humans, immunotoxicity will occur. 

Deuel, T. et al. (1991). Growth factors and wound healing platelet-derived growth factor as a model cytokine. Arm. Rev. 

The technology of Low Level Laser Therapy (LLLT) was introduced into clinical medicine more than three decades ago. This form of treatment has great appeal due to its novelty, ease in use, relatively cost-efficient and low morbidity profile [5], LLLT has been shown to improve remarkably the process of wound healing in humans [5-8] and animal models [9-11], In vitro studies demonstrated that LLLT has a stimulating effect on cell mitosis [12] and proliferation and migration of fibroblasts [13], keratinocytes [14, 15] and endothelial cells [16], LLLT enhances NO secretion [17] and cytokine production [18, 19] and may lead to increased dermal angiogenesis [20],... 

Abstract The utility of confocal Raman microscopy to study biological events in skin is demonstrated with three examples, (i) monitoring the spatial and structural differences between native and cultured skin, (ii) tracking the permeation and biochemical transformation in skin of a Vitamin E derivative and (iii) tracking the spatial distribution of three major skin proteins (keratin, collagen, and elastin) during wound healing in an explant skin model. 

Vibrational microspectroscopy provides a unique means for molecular level structure characterization of a variety of biological processes associated with skin. For the past several years, this laboratory has utilized Raman and IR spectroscopy, microscopy, and imaging to monitor the biophysics of the skin barrier, mechanisms of drug permeation and metabolism in intact tissue, and, more recently, the complex events that transpire during wound healing in an ex vivo skin model [1-6]. 

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