Wound healing, aberrant

Kock, R.J., Goode, RE., and Simpson, G.T. (1997) Serum Free Keloid Fibroblast Cell Culture An In Vitro Model for the Study of Aberrant Wound Healing, Blast. Reconstr. Surg. 99, 1094-1098. 

Shifts in the cutaneous microbiome have also been noted in chronic ulcer disease, such as those caused by venous stasis or diabetes (175). Patients with chronic ulcers treated with antibiotics have been shown to have an increased abundance of Pseudomonadaceae while an increase in Streptococcaceae has been noted in diabetic ulcers (175). A longitudinal shift in wound microbiota has also been shown to coincide with impaired healing in diabetic mice, and may interact with aberrantly expressed host cutaneous defense response genes leading to ulcerogenesis (176). When compared to controls, the feet of diabetic men has also been noted to have decreased populations of Staphylococcus species, a relative increase in the population of S. aureus and increased bacterial diversity, which may increase the risk for wound infections in diabetic patients (177). 

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