Wound-Healing Response of Bone

Glycosyl Transferases. These enzymes are responsible for the sequential addition of carbohydrate molecules to proteins to form proteoglycans, and ultimately connective tissue and cartilage. They are therefore important for the structural integrity of bone and skin, and for normal wound healing. 

The typical injury of scurvy consists of an incapacity of the mesenchymal cells—such as fibroblasts, osteoblasts, or odontoblasts—to produce their normal fundamental substance. In other words, the cell can proliferate, but it cannot form collagen, osteoid, or dentin. This basic alteration is responsible for increased fragility of the capillaries, retarded wound healing, abnormal bone growth, and eventually abnormal tooth growth [78]. 

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