Protein, wound healing

Hydroxymethyl-6-methyluracil (1043) was prepared many years ago from 6-methyl-uracil and formaldehyde, or in other ways. Since 1956 it has received much attention in the USSR under the (transliterated) name pentoxyl or pentoxil. It is used in several anaemic and disease conditions. For example, a mixture of folic acid and pentoxyl quickly reduces the anaemia resulting from lead poisoning pentoxyl stimulates the supply of serum protein after massive blood loss it stimulates wound healing it stimulates the immune response in typhus infection and it potentiates the action of sulfonamides in pneumococcus infections (70MI21300). 

A topical enzyme aids in the removal of dead soft tissues by hastening the reduction of proteins into simpler substances. This is called proteolysis or a proteolytic action. The components of certain types of wounds, namely necrotic (dead) tissues and purulent exudates (pus-containing fluid), prevent proper wound healing. Removal of this type of debris by application of a topical enzyme aids in healing. Examples of conditions that may respond to application of a topical enzyme include second- and third-degree bums, pressure ulcers, and ulcers caused by peripheral vascular disease An example of a topical enzyme is collagenase (Santyl). 

A substrate is a substance that is the basic component of an organism. Protein substrates are amino acids, which are essential to life Protein substrates are amino acid preparations that act to promote the production of proteins (anabolism). Amino acids are necessary to promote synthesis of structural components, reduce the rate of protein breakdown (catabolism), promote wound healing, and act as buffers in the extracellular and intracellular fluids. Crystalline amino acid preparations are hypertonic solutions of balanced essential and nonessential amino acid concentrations that provide substrates for protein synthesis or act to conserve existing body protein. 

Amino acids promote the production of proteins, enhance tissue repair and wound healing, and reduce the rate of protein breakdown. Amino acids are used in certain disease states, such as severe kidney and liver disease, as well as in TPN solutions. (See the last section of this chapter for a more detailed discussion of TPN.) TPN may be used in patients with conditions such as impairment of gastrointestinal absorption of protein, in patients with an increased requirement for protein, as seen in those with extensive bums or infections, and in patients with no available oral route for nutritional intake ... 

Malnutrition is a significant but reversible risk factor. High-protein diets have been shown in multiple studies to improve wound healing in patients with pressure sores.37... 

Amino acids are provided to preserve or replete lean body mass and visceral proteins and to promote protein anabolism and wound healing. 

Amino acids are the building blocks of body proteins. There is no excess storage form of protein in the body, so amino acids are an essential component of the PN admixture. Amino acids are provided to preserve or replete lean body mass and visceral proteins and to promote protein anabolism and wound healing. Amino acids are a source of calories with a caloric value of 4 kcal/g. 

Protein requirements must be based on the patient s nutrition assessment and appropriate amounts provided (based on IBW or AdjBW for obese patients) to facilitate anabolism and wound healing, and avoid adverse effects (e.g., azotemia and uremia). 

G ft Appropriate varieties Self-regulation Crop wound healing after High ratio protein/total N <0 a... 

Zinc normally aids wound healing in terrestrial invertebrates. Wounding of the optic tentacle, foot tissue, and partial shell removal in Helix aspersa, a terrestrial gastropod, resulted in deposition of zinc in the wound area after 2 to 5 days. Increased zinc in Helix wound areas may be necessary to promote protein synthesis, collagen formation, and mitotic cell division (Ireland 1986). 

Assessing the outcome of EN includes monitoring objective measures of body composition, protein and energy balance, and subjective outcome for physiologic muscle function and wound healing. 

Polyphenol oxidase occurs within certain mammalian tissues as well as both lower (46,47) and higher (48-55) plants. In mammalian systems, the enzyme as tyrosinase (56) plays a significant role in melanin synthesis. The PPO complex of higher plants consists of a cresolase, a cate-cholase and a laccase. These copper metalloproteins catalyze the one and two electron oxidations of phenols to quinones at the expense of 02. Polyphenol oxidase also occurs in certain fungi where it is involved in the metabolism of certain tree-synthesized phenolic compounds that have been implicated in disease resistance, wound healing, and anti-nutrative modification of plant proteins to discourage herbivory (53,55). This protocol presents the Triton X-114-mediated solubilization of Vida faba chloroplast polyphenol oxidase as performed by Hutcheson and Buchanan (57). 

Suzuki K, Tanaka T, Enoki M, Nishida T. Coordinated reassembly of the basement membrane and junctional proteins during cornea epithelial wound healing. Invest Ophthalmol Vis Sci 41 2495-2500 (2000). 

Fibrin—Blood protein involved in blood clotting and wound healing. 

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