Wound healing Mitosis

The technology of Low Level Laser Therapy (LLLT) was introduced into clinical medicine more than three decades ago. This form of treatment has great appeal due to its novelty, ease in use, relatively cost-efficient and low morbidity profile [5], LLLT has been shown to improve remarkably the process of wound healing in humans [5-8] and animal models [9-11], In vitro studies demonstrated that LLLT has a stimulating effect on cell mitosis [12] and proliferation and migration of fibroblasts [13], keratinocytes [14, 15] and endothelial cells [16], LLLT enhances NO secretion [17] and cytokine production [18, 19] and may lead to increased dermal angiogenesis [20],... 

There is considerable evidence that the normal development of cells is for them to undergo limited growth and then divide and that cells which do not continue this life history are cells in which mitosis has become blocked in some way. This hypothesis is supported by the ability of many such non-dividing cells to resume mitosis if appropriately stimulated. Such stimulation is illustrated by the response of certain tissues to mechanical wounding or insect attack (some of the uninjured cells dividing to heal the wound or, in the case of insect attack, to form a gall) and by the plant tumours which result from the... 

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