Tissue wound healing strength

Wound healing strength of various tissue adhesives vs. corresponding controls. 

Sutures are required to hold tissues together until the tissues can heal adequately to support the tensions exerted on the wound duting normal activity. Sutures can be used ia skin, muscle, fat, organs, and vessels. Nonabsorbable sutures are designed to remain ia the body for the life of the patient, and are iadicated where permanent wound support is required. Absorbable sutures are designed to lose strength gradually over time by chemical reactions such as hydrolysis. These sutures are ultimately converted to soluble components that are then metabolized and excreted ia urine or feces, or as carbon dioxide ia expired air. Absorbable sutures are iadicated only where temporary wound support is needed. 

However, at this level of intake, the subjects in the Sheffield study had impaired wound healing, as assessed by the tensile strength of scar tissue. Optimum wound healing required a mean intake of 20 mg per day. Allowing for individual variation, this gives a reference intake of 30 mg per day, which was the British reference intake until 1991 and the World Health Organization reference intake until 2001. 

It must be noted that the biomechanics of certain wound sites may limit the use of PEG-based polymer adhesives as the sole modality for wound closure. In this instance, a combination of novel gel-forming adhesives with a fewer number of staples or stitches than traditionally practiced may achieve adequate skin closure and wound healing with less tissue trauma. In a study done by Allan and colleagues, skin incisions were performed upon the dorsum of rats. As a control, some of these wounds were closed with either sutures or staples in the traditional manner (two sutures/staples per centimeter of wound). The study group consisted of wounds closed with polymer adhesive plus half the number of staples/sutures (one suture/staple per centimeter). The tensile strengths of the wounds of the control and study... 

Virtually every operation requires the use of materials to close the wound for subsequent successful healing. The material must retain adequate strength during the critical period of healing it should also induce minimal tissue reaction that might interfere with the healing process. The complexity involved in wound healing calls for different types of wound closure materials. 

Bacterial cellulose Mechanical strength High porosity Surgery and wound dressings Dental implants Transfer of antibiotics Blood vessels Tissue engineering Wound healing 2,83,117... 

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