Tablets protection

The sodium salt of valproate is marketed in Europe as a tablet protected by aluminum foil, as it is quite hygroscopic. In Central and South America, the magnesium salt is available, which is considerably less hygroscopic. The free acid of valproate was first marketed in the USA in a capsule containing com oil the sodium salt is also available in syrup, primarily for pediatric use. 

White pigmented shellac is used as a primer—sealer for iaterior appHcations. Shellac is used as a protective coating for pharmaceuticals to maintain the potency of medication. Several coats of shellac gla2e protect medication from the effects of stomach acids so that the medication is not released before the tablet reaches the intestines. 

Pharmaceutical Applications. Sucrose has a long history in the manufacture of pharmaceuticals. It imparts body to symps and medicinal hquids and masks unpleasant tastes. Sucrose also functions as a diluent to control dmg concentrations in medicines, as an ingredient binder for tablets, and to impart chewiness to the latter. Sustained-release medications and protective tablet glazes are prepared using sucrose (41). Sucrose-based sugar pastes are used to promote wound healing (58). 

Delivery systems that respond to changes in pH have been known to the pharmaceutical industry for more than a century. The pH-sensitive enteric coating is probably the oldest controUed-release technology. Unna introduced an enteric tablet coating based on keratin in 1884 (108). Enteric coatings are used primarily to protect the gastric mucosa from local irritation or to ensure that tablets do not dissolve until they reach the intestine. 

Vapor-phase inhibitors are volatile compounds that adsorb onto metal surfaces, and retard or prevent corrosion by a variety of mechanisms (37). Inhibitors such as dicyclohexamine nitrate [3882-06-02] can protect a variety of metals such as steel, aluminum, and tinplate. A number of vapor-phase inhibitors are commercially available as powders or tablets. However, vapor-phase inhibitors attack nonferrous metals to varying degrees, thus the manufacturers recommendations should be checked before appHcation. The system to be protected must be closed to maintain the volatile compound, but objects as large as the interior of an ocean-going tanker have been treated by this technique. 

Mesalamine—Swallow tablets whole do not chew them. For the suppository, remove foil wrapper and immediately insert tiie pointed end into the rectum without using force. For tiie suspension form, instructions are included with the product. Shake well, remove the protective sheath from the applicator tip, and gently insert the tip into the rectum. Partially intact tablets may be found in the stool if this occurs, notify the primary health care provider. 

On the evidence given here, the tablet conditioner seemed to work well, but the geometrical positions associated with the means (1.249, 1.775) differ from those with the means (1.069. .. 1.107) indeed, five of these positions were near the entry port of the controlled-humidity airstream, and the other two were situated in comers somewhat protected from the air currents. The 1.159 group marks the boundary of the acceptable region. 

In some instances there is a possibility that the efficacy of these preparations may be compromised by conditions associated with the digestive tract. Most function at pH values approaching neutrality. They would thus display activity possibly in saliva and particularly in the small intestine. However, the acidic conditions of the stomach (where the pH can be below 1.5) may denature some of these enzymes. Furthermore, the ingested enzymes would also be exposed to endogenous proteolytic activities associated with the stomach and small intestine. Some of these difficulties, however, may be at least partially overcome by formulating the product as a tablet coated with an acid-resistant film to protect the enzyme as it passes through the stomach. 

Potassium iodine tablets can be used to reduce radioactive iodine exposure to the thyroid gland. According to the National Council of Radiation Protection and Measurement (NCRP), taking 130 milligrams of potassium iodine at or before exposure to radioactive iodine effectively blocks nearly 100% of radioactive iodine from reaching the thyroid.1 Waiting 4 hours after exposure to take potassium iodine... 

Some quality factors, especially secondary ones, depend directly on material or structural attributes of the product. These product quality factors are often arbitrary and can only be qualitatively evaluated by panels of consumers or experts. Convenience for use, product stability, and ability for human skin protection are all examples of these quality factors. Each arbitrary performance index has specific relationships with the material/structural attributes. In such cases, the desirable quality factor can be realized by directly changing the formulation without concerning any of the performance indices. An example can be that to make a laundry detergent product more convenient to use, the product form can be changed from powder to tablet. Another example is that to make a highly biodegradable product, surfactants with less branching should be used. 

The protection of a drug substance from the destructive influences of atmospheric oxygen or humidity (such as coated tablets, sealed ampuls)... 

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