Bum wounds, healing

Human growth hormone, used as a human pharmaceutical, is approved for only one indication in the United States, treatment of growth failure owing to hGH deficiency, a condition known as pituitary dwarfism. However, clinical trials are under way to test its efficacy in Turner s syndrome, bums, wound healing, cachexia, osteoporosis, constitutional growth delay, aging, malnutrition, and obesity. 

R. Maenthaisong, N. Chaiyakunapruk, S. Niruntrapom, C. Konqkaew (2007) The efficacy of aloe vera used for bum wound healing A systematic review. Bums, 33, 713-718. 

Alemdaroglu, C., Degim, Z., Celebi, N., Zor, F., Ozturk, S., Etdogan, D., 2006. An investigation on bum wound healing in rats with chitosan gel formulation containing epidermal growth factor. Bums 32, 319—327. 

Liu M, Dai Y, Li Y, Luo Y, Huang F, Gong Z, Meng Q (2008) Madecassoside isolated Ifom Centella asiatica herbs facilitates bum wound healing in mice. Planta Med 74 809-815... 

Shakespeare P. Bum wound healing and skin substitutes. Burns 2001 27 517-22. 

In medicine, chitosan films indicated antibacterial activities against Escherichia Coli, Staphylococcus aureus and Pseudomonas aeruginosa and has been used for bum wound healing. 

A topical enzyme aids in the removal of dead soft tissues by hastening the reduction of proteins into simpler substances. This is called proteolysis or a proteolytic action. The components of certain types of wounds, namely necrotic (dead) tissues and purulent exudates (pus-containing fluid), prevent proper wound healing. Removal of this type of debris by application of a topical enzyme aids in healing. Examples of conditions that may respond to application of a topical enzyme include second- and third-degree bums, pressure ulcers, and ulcers caused by peripheral vascular disease An example of a topical enzyme is collagenase (Santyl). 

Amino acids promote the production of proteins, enhance tissue repair and wound healing, and reduce the rate of protein breakdown. Amino acids are used in certain disease states, such as severe kidney and liver disease, as well as in TPN solutions. (See the last section of this chapter for a more detailed discussion of TPN.) TPN may be used in patients with conditions such as impairment of gastrointestinal absorption of protein, in patients with an increased requirement for protein, as seen in those with extensive bums or infections, and in patients with no available oral route for nutritional intake ... 

It is used in the form of silver salts (sulfadiazine silver) as an external antibacterial agent, primarily for treating bums. It is believed that the presence of the silver ion in the molecule facilitates increased antimicrobial and wound-healing action. 

Alee Vera (Aloe barbadensis) Uses Topically for bums, skin irritation, sunburn, wounds internally used for constipation, amenorrhea, asthma, colds Actions Multiple chemical components aloinosides inhibit H20 electrolyte reabsorption irritates colon which T peristalsis propulsion wound healing d/t i production of thromboxane A2, inhibiting bradykinin, histamine Available forms Apply gel topically 3-5/d PRN caps 100-200 mg PO hs Contra Do not use if PRG, lactating, or children <12 y Notes/SE Abd cramping, D, edema, hematuria, hypokalemia, muscle weakness, dermatitis Interactions w/ internal use T K+ loss W/ BB, corticosteroids, diuretics, licorice T effects OF antiarrhythmics, corticosteroids, digoxin, diuretics, hyperglycemias, jimsonweed EMS Assess for dehydration, electrolyte imbalance (hypokalemia), abd distress w/ internal use stimulates uterine contractions may cause spontaneous abortion... 

Bruises, bums, ulcers, healing wounds (use externally only)... 

Eldad, A., Weinberg, A., Breiterman, S., Chaouat, M., Palanker, D., Ben-Bassat, H. (1998). Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness bums. Burns 24 166-72. 

Graham, J.S., Chilcott, R.P., Rice, P., Milner, S.M., Hurst, C.G., Maliner, B.I. (2005). Wound healing of cutaneous sulfur mustard injuries strategies for the development of improved therapies. J. Bums Wounds 4 el. 

Graham, J.S., Schomacker, K.T., Glatter, R.D., Briscoe, C.M., Braue, E.H., Jr., Squibb, K.S. (2002b). Bioengineering methods employed in the study of wound healing of sulphur mustard bums. Skin Res. Technol. 8 57-69. 

Prevents and treats C deficiency (scurvy) increases wound healing for bums sickle cell crisis deep vein thrombosis. Megavitamin therapy (massive doses) of vitamins is not recommended it can cause toxicity. 

Ascorbic acid, a water-soluble vitamin (1(X) to 250 mg p.o. daily), is indicated in the treatment of frank and subclinical scurvy in extensive bums, delayed fracture or wound healing, postoperative wound healing severe febrile or chronic disease states and in prevention of ascorbic acid deficiency in those with poor nutritional habits or increased requirements. In addition, ascorbic acid has been used for potentiation of meth-enamine in urine acidification and as an adjunctive therapy in the treatment of idiopathic methemoglobinemia. 

In immunocompromised patients with mucocutaneous HSV infection, intravenous acyclovir (250 mg/vtf every 8 hours for 7 days) shortens healing time, duration of pain, and the period of virus shedding. Oral acyclovir (800 mg five times per day) and valacyclovir (1000 mg twice daily) for 5-10 days are also effective. Recurrences are common after drug cessation and may require long-term suppression. In those with very localized labial or facial HSV infections, topical acyclovir may provide some benefit. Intravenous acyclovir may be beneficial in viscerally disseminating HSV in immunocompromised patients and in patients with HSV-infected bum wounds. 

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