Wound-healing Accelerators

The rapid healing of wounds is desirable for patients, especially those suffering from diabetes, because they show an extremely slow rate of healing. Chitin and chitosan have been investigated by many researchers for a long time as possible wound-healing accelerators [143,144]. Chitin and its derivatives can be applied safely to animals, as well as the humans. 

Various forms of chitin-based products are available for medical applications, such as finely divided powder, nonwoven fabrics, porous beads, lyophilized soft fleeces or gels, gauges, laminated sheets, and transparent films. Water-soluble derivatives of chitin in isotonic saline can be administered intramuscularly or intravenously. Certainly, there is considerable biochemical evidence linking NAG with the metabolism of the hexamines, which are assumed to originate and cross-link wound collagen. 

---

Actions External use antibacterial, antimicrobial, antiviral, wound healing accelerator, anti-inflammatory, antiulcer. Internal use purgative, stimulates smooth muscle contractions. 

Honey is one alternative less desirable choices include echinacea and St. John s wort for wound healing acceleration and to prevent scarring. 

Prudden, J. G., Migel, P, Hanson, P, Friedrich, L. and Balassa, L., The discovery of a potent pure chemical wound-healing accelerator. Am.. Surg., 119, 560, 1970. 

D.-K. Kweon, S.-B. Song, Y.-Y. Park, Preparation of water-soluble chitosan/heparin complex and its application as wound healing accelerator, Biomaterials 24 (2003) 1595-1601. 

Gouda, M. (2011). Nano-zirconium oxide nano-silver oxide/cotton gauze fabrics for antimicrobial and wound healing acceleration. Journal of Industrial Textiles, 41(3), 222—240. 

Wound healing acceleration Allantoin 2-N heterocyclic alkaloid 490... 

Matsuda, H., Koyama, H., Sato, H., Sawada, J., Itakura, A., Tanaka, A., Matsumoto, M., Konno, K., Ushio, H., and Matsuda, K. 1998. Role of nerve growth factor in cutaneous wound healing Accelerating effects in normal and healing-impaired diabetic mice. Journal of Experimental Medicine, 187,297-306. 

Chitin and its deacetylated product, chitosan, have attracted renewed scientific and economic interest because of their abrmdance, especially the availability fi om seafood waste, and unique attributes, e.g. biodegradability, biocompatibility, nontoxicity, wound-healing acceleration, antimicrobial and chelating properties. Chitin and chitosan have been widely used in food, biomedical, cosmetic, and textile applications. By fabricating chitin and chitosan fibers, one could take better advantage of the bioactive properties and broad the applications of these polymers. 

---