Wounds epidermal healing

Epidermal Maturation and Wound Healing. All three PPAR isotypes are expressed during epidermal maturation each isotype has a specific pattern of expression in regard to development and the various layers of the epidermis. An important role for PPARS in the development and/or maintenance of normal skin health is indicated by the presence of defective wound healing in the PPARS-null mouse. 

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing. J. Biol. Chem. 267, 21277-21280. 

Wound healing Epidermal growth factor Eibronectin Insulin-like growth factor... 

Brown LF, Yeo KT, Berse B, Yeo TK, Senger DR, Dvorak HF, Van de Water L. 1992. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J Exp Med 176 1375-1379. 

Wahli, W. Peroxisome proliferator activated receptors from metabolic control to epidermal wound healing, Swiss Med. Wkly, 132, 83, 2002. 

Lanolin does not have a detrimental effect on epidermal homeostasis of clinically normal skin or healing of wounds. In contrast to oils, such as olive oil and mineral oil, lanolin does not have adverse effects on the homeostasis of normal epidermis 48 Butcher found that repeated application of olive oil and mineral oil resulted in acanthosis and parakeratosis, which is abnormal proliferation and differentiation 48... 

Chvapil et al. investigated the effects of epidermal growth factor (EGF) in a lanolin vehicle on partial thickness wounds 49 A beneficial effect of lanolin vehicle was observed with little additional benefit from EGF. Lanolin statistically increased the rate of reepithelialization, the thickness of the dermis, and the number of cells in the dermis. Lanolin is likely to promote wound healing by maintaining a moist environment.50,51... 

Chvapil, M., Gaines, J.A., and Gilman, T., Lanolin and epidermal growth factor in healing of partial pig wounds, J. Bum Care Rehabil., 9, 279, 1988. 

The HD-induced dermal lesion is characterized by vesication and slow wound healing. Our laboratory has shown that the epidermal-dermal separation associated... 

Epidermal keratinization and mucous membrane squamous metaplasia respond to both oral and topical vitamin A therapy. Vitamin A exists in three forms retinol, retinal, and retinoic acid.VitaminA increases the mucous production of goblet cells and perhaps the aqueous and lipid components of the tears as well. Tretinoin is a normal metabolite and the carboxylic form of retinol. Retinol is present in tears and the lacrimal gland appears to be its major provider. Retinoic acid has been shown to be effective in ocular surfece disorders such as squamous metaplasia by reversing the corneal and conjunctival keratinization and improving epithelium wound healing rate. 

Nagy A, Nagashima H, Cha S, Oxford GE, Zelles T, Peck A, Humphreys-Beher MG. Reduced oral wound healing in the NOD mouse model for type 1 autoimmune diabetes and its reversal by epidermal growth factor supplementation. Diabetes 2001 50 2100-2104. 

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