Pituitary dwarfism

Human growth hormone, used as a human pharmaceutical, is approved for only one indication in the United States, treatment of growth failure owing to hGH deficiency, a condition known as pituitary dwarfism. However, clinical trials are under way to test its efficacy in Turner s syndrome, bums, wound healing, cachexia, osteoporosis, constitutional growth delay, aging, malnutrition, and obesity. 

Pituitary Dwarfism. Pituitary dwarfism is a condition characterized by an inabiHty to produce or secrete normal levels of endogenous hGH. The condition results in reduced heights of individuals afflicted with the condition and has been treated by intramuscular or subcutaneous injection of hGH. Pituitary hGH was used prior to the approval of biosynthetic hGH. If treatment is initiated early enough, the patient can attain a final adult height weU within the normal range. 

Human somatotropin 191 amino acids E. coll Pituitary dwarfism Approved for sale If useful in treatment of osteoporosis then market size will be much larger Has additional methionine residue at N-terminus, but technology for removing this now available... 

GH has a potentially wide range of therapeutic uses (Table 11.6). To date, however, its major application has been for the treatment of short stature. hGH extracted from human pituitary glands was first used to treat pituitary dwarfism (i.e. caused by suboptimal pituitary GH secretion) in 1958. It has subsequently proven effective in the treatment of short stature caused by a variety of other conditions, including ... 

Various studies have confirmed that rhGH promotes increased linear growth rates in children suffering from pituitary dwarfism (classical growth hormone deficiency). Dosages are generally... 

Pituitary dwarfism -treatment using hGH [HORMONES - HUMAN GROWTH HORMONE] (Vol 13)... 

A substance isolated from human pituitary (e.g. Asellacrin ) is available for the treatment of pituitary dwarfism in which there is a confirmed STH deficiency. 

Alpha-1-antitrypsin gene gene therapy—alpha-1-antitrypsin deficiency growth hormone thyroid stimulating hormone DA VP pituitary dwarfism hypothyroidism enuresis... 

Growth Androgens are used in conjunction with other hormones to promote skeletal growth in prepubertal boys with pituitary dwarfism. 

The well-known, but fortunately, rare, pituitary dwarfism is due to the lack of growth hormone (somatotropin). Normal growth can be restored by the administration of the hormone during adolescence. In spite of its obvious importance, we can not discuss here the history of growth hormone it is a... 

Hypopituitarism may involve all the hormones of the anterior hypophysis, or it may be restricted to one or a few hormones of the anterior lobe, depending on the patient s age. General hypopituitarism of the anterior lobe results in pituitary dwarfism, infantilism, and Simmonds cachexia. The restricted forms of hypopituitarism lead to well-known clinical syndromes such as Frohlich s and the Laurence-Moon-Biedl syndrome. 

Pituitary dwarfism may be acquired or hereditary. A dwarf is defined as a person whose stature is 40% lower than normal or three standard deviations to the left of the mean. The causes of dwarfism are numerous. In addition to damage to the hypothalamus and... 

May be responsible for pituitary dwarfism III. Tumors of the posterior lobe of the hypophysis... 

Genetic pituitary dwarfism with hi serum ooncentratigrowth hormone. A new inborn error of metabolism ... 

Bierich JR (1986). Treatment of pituitary dwarfism with biosynthetic growth hormone. Acta Paediatrica Scandinavica (Suppl), 325 13-18. 

Holmstrom, B. and Fholenhag, K. (1975) Characterisation of human growth hormone preparations used for the treatment of pituitary dwarfism a comparison of concurrently used batches. J. din. Endocr., 40, 856. 

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