Wound healing proliferation phase

Figure 14.9 Major events that occur during the four phases of wound healing (a) homeostasis (b) inflammation (c) proliferation and (d) maturation and tissue remodeling.

As a natural constituent of connective tissue and major structural protein, collagen is implicated in all phases of the wound healing process (hemostasis, inflammation, migration, proliferation and maturation) and controls the cellular functions such as cell shape and differentiation, migration, and synthesis of a number of proteins [100]. The use of collagen dressings may seem attractive in view of their functions to ... 

Wound healing is a dynamic process consisting of three overlapping phases inflanunation, proliferation and maturation (restructuring). 

Vitamin A is essential for epidermal proliferation and reepithelialisation binding of retinol to cell surface receptors. It is also important in the inflammatory phase of the chronic wound healing process, which is one of the main reasons for delayed healing. Vitamin A is also related with collagen synthesis and infection. Vitamin B promotes cell proliferation, which helps healthy skin and muscle tone, and also enhances immune and nervous system function. 

Wound healing is a complex phenomenon where angiogenesis, ie formation of new blood vessels plays an essential role (Bates and Jones, 2003). The wound healing process can be divided into three main phases inflammatory phase, proliferation phase, and maturation and remodeling phase (Witte and Barbul, 1997), as discussed in the following text (Eig. 10.1). 

Fig. 10.1 Main stages of wound healing. (A) Inflammatory phase. (B) Proliferation phase. (C) Maturation and remodeling phase.

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