Role in wound healing

Vimentin is thought to play a role in wound healing (Mor-Vaknin et al.,... 

Transforming growth factor-p (TGF-p) is a group of several isoforms that have several roles in wound healing and other aspects of cell growth. It is now believed that there are five members of the TGF-p family. These compounds, of which TGF-pi is... 

PDGF, which plays an important role in wound healing (cicatrization), is a dimer formed by two polypeptides. There are two isoforms of this protein that are most commonly encountered in the human body one with 110 amino acids and another with 125. Both isoforms have one glycosylation site and three disulfide bonds. 

Basic fibroblast growth factor (bFGF) is a potent mitgen that stimulates the proliferation of a wide variety of cells and could play a crucial role in wound healing processes. The therapeutic potential of bFGF has not been fully realized, however, because of its susceptibility to proteolytic inactivation and short duration of retention at the site of action. Sulfated oligosaccharides, including a sodium salt of... 

Martins-Green, M., and Hanafusa, H. (1997). The 9E3/CEF4 gene and its product the chicken chemotactic and angiogenic factor (cCAF) potential roles in wound healing and tumor development. Cytokine Growth Factor Rev. 8, 221-232. 

These two reports 10 years apart reflect the continuing interest in heparin combinations playing a multifactorial role in wound healing. The role of heparin alone has also received considerable attention. Considerable research has looked at the role of heparin in anticoagulation but in the context of cutaneous wound healing the focus is on topical application. 

A composite film was prepared by the addition of 10—30% chitosan into keratin (Khor and Lim, 2003). This film exhibited improved resistance to bacteria and supported fibroblast attachment and proliferation, suggesting a role in wound healing for keratin—chitosan films. Moreover, the preparation of a bilayered chitosan membrane proved its effectiveness for controlling of infection. Such a membrane uses a thin layer of chitosan as an antibacterial and moisture control barrier attached to a sponge layer that could absorb wound exudates. Additionally, the bilayered chitosan... 

These polyglycans have important and varied psychological roles in animal tissue. Hyaluronic acid, for instance, is known to occur in the dermis of the skin, in the vitreous fluids of the eye, and in the body s synovial fluids (67). It has many functions, the most significant being cellular turgidity (because of its water-binding capacity) and lubrication. It has also been shown to play a key role in wound healing, which will be discussed in Section lll.F.l. 

Olczyk, P, et al., Hyaluronan Structure, metabolism, functions, and role in wound healing. Postepy Higieny I Medycyny Doswiadczalnej, 62 651-659,2008. 

Although red blood cells (erythrocytes) play only a minimal role in wound healing and blood-biomaterial interactions, the contact of red blood cells with the material can lead to hemolysis. Hemolysis is the breakage of the erythrocyte s membrane with the release of intracellular hemoglobin. Normally, red blood cells live for 110-120 days. After that, they naturally break down and are removed from the circulation by the spleen. Some diseases and medical devices cause red blood cells to break too soon requiring the bone marrow to accelerate the regeneration of red blood cells (erythropoesis). Medical devices for hemodialysis, heart-lung-bypass machines or mechanical heart valves induce more hemolysis than smaller implants like stents or catheters [201]. 

Fibroblast A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals. 

Table m. Example Growth Factors And Their Role in Wound Healing... 

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