Adhesive wound healing strength

Wound healing strength of various tissue adhesives vs. corresponding controls. 

It must be noted that the biomechanics of certain wound sites may limit the use of PEG-based polymer adhesives as the sole modality for wound closure. In this instance, a combination of novel gel-forming adhesives with a fewer number of staples or stitches than traditionally practiced may achieve adequate skin closure and wound healing with less tissue trauma. In a study done by Allan and colleagues, skin incisions were performed upon the dorsum of rats. As a control, some of these wounds were closed with either sutures or staples in the traditional manner (two sutures/staples per centimeter of wound). The study group consisted of wounds closed with polymer adhesive plus half the number of staples/sutures (one suture/staple per centimeter). The tensile strengths of the wounds of the control and study... 

Such bioadhesive materials were also examined for the controlled release of growth factors and other proteins [77-82]. Of particular interest was the investigation of mucoadhesive PVA gels for use in epidermal bioadhesive systems for the controlled release of epidermal growth factor or ketanserin to accelerate wound healing [78]. Such systems were examined not only for their drug-release properties but also for their strength and adhesive characteristics. 

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