Cancer colonic

Colon cancer Colonic cancer Colonocytes Colonoscopy... [Pg.239]

Folate antagonists (eg, methotrexate and certain antiepileptics) are used ia treatment for various diseases, but their adininistration can lead to a functional folate deficiency. Folate utilization can be impaired by a depletion of ziac (see Zinc compounds). In humans, the intestinal bmsh border folate conjugase is a ziac metaHoenzyme (72). One study iadicates that the substantial consumption of alcohol, when combiaed with an iaadequate iatake of folate and methionine, may iacrease the risk of colon cancer (73). Based on this study, it is recommended to avoid excess alcohol consumption and iacrease folate iatake to lower the risk of colon cancer. [Pg.42]

Colorectal Cancer. Colorectal cancer occurs frequently in the UK population but is historically rare in Asia. Rates in Japan have, however, increased rapidly in recent years.Interestingly, there appears to be an association between oestrogen exposure and colon cancer risk has been shown to increase in women with increasing age of first live birth, and to decrease with increasing parity (number of children). In addition, many colon tumours express sex hormone receptors, and this is thought to play a part in development of the tumours. "... [Pg.126]

As noted above, geographical and temporal differences in the incidence of colon cancer are well established (see also Table 3). This has led to the suggestion that diet may play a key role, with low colon cancer incidences being linked with vegetarian or semi-vegetarian diets. "... [Pg.126]

It is important to note that diet is a complex mixture that contain compounds with varying activity. Chemical stimulators of colon cancer growth include bile acids, 1,2-diglycerides and prostaglandins which stem from consumption of fat. In contrast, fruits and vegetables contain substances such as carotenoids, flavonoids and fibre, which may inhibit cancer cell growth, and the risk of colon cancer appears to be mirrored by the ratio of plant sterols to cholesterol in the... [Pg.126]

Selective AR agonists are undergoing clinical trials for cardiac arrhythmias and pain (Ai) cardiac imaging and inflammation (A2a) colon cancer, rheumatoid arthritis, psoriasis, and dry eye (A3). Selective AR antagonists are either in or advancing toward clinical trials for kidney disorders (Ax) Parkinson s disease (A2a) diabetes and asthma (A2B) cancer and glaucoma (A3). [Pg.27]

In vitro nifedipine inhibits proliferation of colon cancer cells with a DNA mismatch repair defect that are resistant to 5-fluorouracil. Whether this also... [Pg.299]

A number of inhibitors directed towards the active site of PKC have been developed [4]. Many of these have therapeutic potential and some are in clinical trials. The drug enzastaurin (LY317615) shows selectivity towards inhibiting PKC 3 and is currently in clinical trials for cancer. This drug has particular potential as a treatment for colon cancer because of the specific role ofPKC (311 in this disease (see above). A separate PKC (3 inhibitor, ruboxistaurin (LY333531) has been developed as a drug to treat the microvasculature complications of diabetes hyperactivation of both PKC (311 and PKC (31 contribute to diabetic retinopathy and microvasculature complications. [Pg.1008]

Stein U, Arlt F, Walther W et al (2006) The metastasis-associated gene S100A4 is a novel target of p-catenin/ T-cell factor signaling in colon cancer. Gastroenterology 131 1486-1500... [Pg.1106]

Combination therapy Nausea, vomiting, diarrhea, in patients with Dukes stomatitis, anorexia stage C colon cancer... [Pg.590]

MEL A498, renal cancer EVSA-7, mammary cancer H226, lung cancer IGROV, ovarian cancer Ml 9, melanoma MCE-7, mammary cancer WiDr, colon cancer. [Pg.368]

Faulty mismatch repair has been finked to fieredi-tary nonpolyposis colon cancer (HNPCC), one of die most common inherited cancers. Genetic smdies finked HNPCC in some families to a region of cfiromosome 2. The gene located, designated hMSH2, was sub-sequendy shown to encode the human analog of the... [Pg.336]

GARLAND c F, COMSTOCK G w and GARLAND F B (1989) Serum 25-hydroxyvitamin D and colon cancer 8-year prospective study , Lancet, 2, 1176-8. [Pg.41]

GIOVANNUCCI E, STAMPFER M J, COLDITZ G A, HUNTER J, FUCHS C, ROSNER B A, SPEIZER F E and WILLETT w c (1998) Multivitamin use, folate, and colon cancer in women in the Nurses Health Study , Ann Intern Med, 129, 517-24. [Pg.41]

TULLiEZ J and terce f (2000) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells . Cancer Res, 60 1426-33. [Pg.63]

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