Probiotics colon cancer

Administration of the probiotic E. faecium strain probably leads to the competition with and elimination of pathogenic bacteria from the intraepithelial niche. Therefore it can be considered that application of non-pathogenic E. faecium can be a promising method for elimination of pathogenic bacteria in the case of inflammatory bowel disease and colon cancer. The same strain of E. faecium was nsed also for the prevention of febrile neutropenia in lenkemic patients. Tolerance of therapy was excellent without significant adverse effects. However, the administration of the enterococcal strain was not effected in the prevention of febrile neutropenia bnt no febrile episode or infection provoked by the probiotic strain E. faecium was noticed (Mego et al. 2005a, 2006). 

Mego M, Majek J, Koncekova R, Ebringer L, Ciernikova S, Rauko P, Kovac M, Trupl J, Slezak P, Zajac V (2005b) Intramucosal bacteria in colon cancer and their elimination by probiotic strain Enterococcus faecium M-74 with organic selenium. Folia Microbiol... 

Frtrthermore, in all animal studies where mixtures of probiotics and prebiotics were examined, the effect of the combination was greater than the sttm of the two separately, suggesting a synergistic effect of symbiotic compotmds. Based on these studies, considerable attention is being paid to dietary components that can influence the coloitic microflora as well as supplemental probiotics as strategies for colon cancer prevention. 

Reddy, B.S., Prevention of colon cancer by pre- and probiotics evidence from laboratory studies, Br. J. Nutr., 80, S219-223,1998. 

Escamilla J, Lane MA, Maitin V. Cell-free supernatants from probiotic Lactobacillus casei and Lactobacillus rhamrwsus GG decrease colon cancer cell invasion in vitro. Nutr Cancer. 2012 64(6) 871—878. 

Intestinal microecology and cancer A number of studies have focused on the impact of probiotics on intestinal microecology and cancer. Lactobacillus acidophilus, L. casei Shirota strain, and LGG have been shown to have inhibitory effects on chemically induced tumors in animals. Some specific strains of probiotic bacteria are able to bind carcinogens and to downregulate some microbial carcinogenic enzymatic activities. This phenomenon may then reduce carcinogen production and exert a beneficial effect in the colon, the urinary tract, and the bladder. 

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