Resveratrol colon cancer inhibited

Hope C, Planutis K, Planutiene M, Moyer MP, Johal KS, Woo J, Santoso C, Hanson JA, Holcombe RF (2008) Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells implications for colon cancer prevention. Mol Nutr Food Res 52(Suppl 1) S52-S61... 

Research in our laboratory has focused on cancer prevention in colon and skin by phytochemicals. We have recently studied apigenin, a tri-hydroxy flavone that is widely distributed in plants and resveratrol, a phytoalexin that is found in grapes, wine, peanuts, and Asian herbs. We initially found that topical apigenin inhibited chemically and ultraviolet (UV)-light induced skin cancer and that it was most effective in preventing cancer promotion. 

Additionally, several reports indicate that -resveratrol inhibits the proliferation of a wide variety of human cancer cells including breast, prostate, colon, gastric, lung, pancreatic, liver, thyroid, and ovarian cancers, leukemia, lymphoma, osteosarcoma, squamous cell carcinoma, multiple myeloma, and medulloblastoma [135]. Among the other stilbenoids, piceatannol, a- and s-viniferin, hopeaphenol, pallidol, ampelopsin A, vaticanol B and C, and pterostilbene also showed cytotoxicity and/or antiproliferative effect on different tumor cell lines [136-145]. 

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