Colon cancer, chemoprevention

Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. Modulation of apoptosis by sulindac, curcumin, phenylethyL3-methylcaffeate, and 6-phenylhexyl isothiocyanate apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res 1997 57 1301-1305. 

Chan, T.A, Nonsteroidal anti-inflammatory drags, apoptosis, and colon-cancer chemoprevention. Lancer Omco/., 3,166-174,2002. 

Rigas, B. and Williams, J.L., NO-releasing NSAIDs and colon cancer chemoprevention a promising novel approach, Int. J. Oncol, 20, 885-890,2002. 

Wargovich, M.J., Colon cancer chemoprevention with ginseng and other botanicals, J. Korean Med. Sci, 16 (Suppl.), S81, 2001. 

Rao, C.V. (2004). Nitric oxide signaling in colon cancer chemoprevention. Mutat. Res. 555, 107-119. 

Williams, J.L., Borgo, S., Hasan, I., Castillo, E., Traganos, E, and Rigas. B. (2001). Nitric oxidereleasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs implications for colon cancer chemoprevention Cancer Res. 61, 3285-3289. 

Hagos, G.K., Carroll, R.E., Kouznetsova, T., Li, Q., Toader, V., Fernandez, P. A., Swanson, S.M., and Thatcher, G.R. (2007). Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Mol. Cancer Ther. 6, 2230-2239. 

Studies by Hudson et al, (2000) have demonstrated the presence of eight polyphenols in rice bran by using high-pressure liquid chromatography. They are protocatechuic acid, p-coumaric acid, ferulic acid, sinapic aci vanillic acid, caffeic acid, which is a methoxycirmamic acid derivative, and tricin. The effect of these polyphenols on cell viability and on the colony-forming ability of human-derived MDA MB 468 and HBL 100 breast cells, colon-derived SW 480 and human colonic epithelial cells was assessed. These authors concluded that rice bran polyphenols have putative cancer chemopreventive properties. 

HUDSON A, DiNH p A, KOKUBUN T, siMMONDS M s, GESCHER A (2000) Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells. Cancer Epidemiol Biomarkers Prev, 9 (11) 1163-70. 

Additional agents, including selenium, folic acid, and HMG-CoA reductase inhibitors (statins), show promise as chemopreventive agents in colon cancer, and preliminary and confirmatory studies evaluating their effectiveness have been completed or are ongoing, although none of these agents have been approved for the prevention of colon cancer.46... 

O Brian CA, Ward NE, Gravitt KR, Gupta KP (1995) The tumor promoter receptor protein kinase C a novel target for chemoprevention and therapy of human colon cancer. Prog Clin Biol Res 391 117-120... 

Mutoh M, Takahashi M, Fukuda K, Matsushima-Hibiya Y, Mutoh H, Sugimura T, Wakabayashi K. 2000. Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. Carcinogenesis 21 959 963. 

Wargovich MJ, Chen CD, Jimenez A, Steele VE, Velasco M, Stephens LC, Price R, Gray K, Kelloff GJ. 1996. Aberrant crypts as a biomarker for colon cancer Evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 5 355-360. 

Lamprecht, S. A. and Lipkin, M., 2003, Chemoprevention of colon cancer by calcium, vitamin D and folate molecular mechanisms. Nat Rev Cancer 3, 601—14. 

Figure 6 shows the strategy followed to carry out a global Foodomics study on the chemopreventive effect of dietary polyphenols against HT-29 colon cancer cells (20). In that work, we exploited the benefits of analytical... 

Kawamori,T. Lubet, R., Vernon, E.S., Kell off, C.J., Kaskey, R.B., Rao,V.R. and Reddy, B.S.(1 999) Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Research 59, 597-601. 

Manju, V. and N al i n i, N. (2005) Chemopreventive efficacy of ginger, a naturally occurring anti carcinogen during the initiation, post-initiation stages of 1,2-dimethylhydrazine induced colon cancer. Clinica Chimica Acta 358(1-2), 60-67. 

Kim, D.J. et al., Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU, and DMH, Cancer Lett, 120, 15, 1997. Risio, M. et al.. Apoptosis, cell replication, and Western-style diet-induced tumori-genesis in mouse colon. Cancer Res., 56, 4910, 1996. 

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