Cancer Colon carcinoma

Vasoactive intestinal peptide 28 Small cell lung cancer, colon carcinoma, pancreatic cancer, stomach cancer... 

KIRLIN w G, CAi J, DELONG M J, PATTEN E J and JONES D P (1999) Dietary compoimds that induce cancer preventive phase 2 enzymes activate apoptosis at comparable doses in HT29 colon carcinoma cells , JNutr, 129 1827-35. 

E., Brattain, M. G., Zweibaum, A., Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells a survey of twenty cell lines, Cancer Res. 1988, 48, 1936-1942. 

Wang W, VanAlstyne PC, Irons KA, Chen S, Stewart JW and Birt DF. 2004. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer 48(1) 106—114. 

The other well-known member of this superfamily is CEA or carcinoem-bryonic antigen. CEA is a widely used tumor marker, especially for monitoring patients with diagnosed colorectal cancer (M5). It is a high-molecular-weight (Afr 200,000, approximately) glycoprotein containing about 60% carbohydrate. In normal colonic cells and in well-differentiated colon carcinomas, the distribution of CEA is apical. However, in undifferentiated colonic tumors, CEA is present on all of the cell membrane (J3). Whether this altered subcellular localization of CEA mediates cancer spread is presently unclear. 

In contrast to P-gp and the MRP proteins, the breast cancer resistance protein (BCRP) contains six transmembrane domains and only one ATP-binding domain. It was first cloned from the breast cancer cell line MCF-7 selected in doxombicin, in the presence of the P-gp inhibitor verapamil. It is found in many human tissues, such as the placenta, small intestine, colon, and liver [133], It is localized to the apical membrane of epithelial cells of the small intestine and colon and to the bile canalicular membrane in the liver and is involved in reducing intestinal uptake, increasing hepatobiliary excretion, etc., leading to diminished oral bioavailability. cDNA sequences identical to BCRP and named MXR and ABCP, respectively, were independently isolated from human colon carcinoma cells and human placenta [134], BCRP requires... 

Kraker AJ, Mizzen CA, Hartl BG, Miin J, Allis CD, Merriman RL (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol Cancer Ther 2(4) 401-408... 

There is a disease termed hereditary polyposis. Victims develop a very large number of polyps in their colons, sometimes several thousand. Since the development of a colon polyp is the first step on the road to colon carcinoma, they are at high risk of colon cancer. The associated mutation is in a gene known as the APC gene. 

Anthracyclines Doxorubicin/ adriamycin Melanoma, Ovarian carcinoma, T-cell lymphoma, Colon carcinoma, B-cell lymphoma, Various disseminated refractory malignandes, Breast cancer, Lung cancer, Pancreatic cancer, Liver cancer, Neuroblastoma... 

Modulation of Histone Acetylation by [4-(Acetylamino)-N-(2-Amino-phenyl) Benzamide] in HCT-8 Colon Carcinoma. Molecular Cancer Therapeutics, 2, 401—4-08. 

Greenhalgh DA, Parish JH. Effect of 5-fluorouracil combination therapy on RNA processing in human colonic carcinoma cells. BrJ Cancer 1990 61 415 -19. 

Matsui S, Arrendondo A, Wrzosek C, et al. DNA damage and p53 induction do not cause ZD 1694-induced cell cycle arrest in human colon carcinoma cells. Cancer Res 1996 56 4715-4723. 

Lawrence TS, Chang EY, Hahn TM, Shewach DS. Delayed radiosensitization of human colon carcinoma cells after a brief exposure to 2, 2 -difluoro-2 -deoxycytidine (Gemcitabine). Clin Cancer Res 1997 3(5) 777-782. 

Shewach DS, Hahn TM, Chang E, et al. Metabolism of 2 -2 difluorodeoxycytidine and Radiation Sensitization of Human Colon carcinoma cells. Cancer Res 1994 54 3218-3223. 

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