Human colon cancer HCT

Aschele C, Sobrero A, Faderan MA et al. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 1992 52 1855-1864. 

Lenthionine (48) and varacin (100) exhibit antifungal activity varacin also exhibits cytotoxicity toward human colon cancer HCT <81TL1739,91JA4709>. 

Trichodermamides A and B are tetracyclic amides containing an oxazine and a lactone. These cytotoxic derivatives against human colon cancer HCT-116 come from the culture of Trichoderma virens collected from the tunicate Didemnum molk harvested in Papua New Guinea (Garo et al., 2003). The genus Trichoderma is well known in a terrestrial environment and was also found on Ghlorophy-ceae of the genus Halimeda. 

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