Colon cancer chemical induction

Multiple premalignant stages are apparent during chemical induction of skin and liver cancer (Farber, 1984), and multistage processes have been identified also in experimental lung (Yarita et colon cancer (Thumherr et al., 1973) as well. In chemically initiated mouse skin... 

Experiments with chemically induced colon cancer in the rat have partially, but not consistently, supported the dietary fiber hypothesis (12). Thus, Bauer et al. (13,14) recently reported that both high- and low-methoxylated pectin (6.5 or 5% in a diet containing 20% casein, 20% fat and no other dietary fiber) given during induction of colon cancer with subcutaneous 1.2-dimethyl— hydrazine, enhanced the yield of tumors. Guar gum, 5%, also tended to increase the tumor yield, although not significantly compared with controls on a virtually fiber-free diet. Others(15) however reported a protective effect of 15% pectin. 

---