Colon cancer risk correlation studies

Thus, the excretory pattern of fecal secondary bile acids observed in these studies correlated with colon tumor incidences in animal models. These studies also suggest that high dietary intake of certain types of fat may be necessary for the full expression of risk for colon cancer. 

Some investigations into caffeine-related health issues are inconclusive. Studies have shown no correlation between caffeine intake and increased risk of osteoporosis or increased risk of spontaneous abortion. There is no conclusive evidence linking caffeine intake (as coffee) with bladder, pancreatic, breast, or colon cancer. There is also no conclusive evidence that moderate caffeine intake contributes to heart disease or heart arrhythmias however, one study has shown that relatively high coffee consumption elevates blood levels of homocysteine (an amino acid)—a situation that may contribute to heart attack or Alzheimer s disease. There is continuing con-... 

Cross-national correlations between the incidence of colon cancer and dietary habits have been used to select hypotheses for testing in case-control and cohort studies. These studies have shown that certain food preferences appear to be associated with either a high- or a low-risk for colon cancer. When such correlations are supported by experimental evidence from animal studies, the hypothesis could be attractive. 

Extrapolation of risk factors from rodent to humans is difficult because of differences in longevity, mobility, and the multistage development of cancer, but correlations can be made between dietary factors and tumor incidence. Based on experimental animal models and epidemiologic investigations, the combined evidence is strongly suggestive for a causal relationship between fat intake and occurrence of cancer for the breast, stomach, and colon. Data from animal studies suggest that increased total fat increases the... 

An obvious factor for the inconsistent results of the effect of different intakes of dietary fiber on colorectal cancer is the variation in the analytical methodology used in different studies. There is also increasing evidence that total dietary complex carbohydrates may be as important as fiber. Analysis of stool weight from 20 populations in 12 countries showed that larger stools were correlated with a lower incidence of colon cancer. Intakes of starch and dietary fiber (rather than fiber alone) were the best dietary correlates with stool weight. A subsequent meta-analysis showed that greater consumption of starch (but not of NSPs) was associated with low risk of colorectal cancer in 12 populations. The examination also showed that fat and protein intakes correlated positively with risk. This meta-analysis is probably the first of its kind to... 

In certain experimental studies, there is an indication for the correlation between the diet rich in carotenoids (p-carotene) and a diminishing risk of cardiovascular diseases and some type of cancer—lung cancer, and probably also cancer of the esophagus, stomach, colon, rectum, breast, and cervix (Kohlmeier and Hastings, 1995 Krinsky, 1991). Presumably, they are capable of seeking for free radicals and neutralizing them and thus they inhibit cell proliferation (Simon, 2002). 

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