1,2-Dimethylhydrazine -induced colon cancer

Chester, J.F., Gaissert, H.A., Ross, J.S. and Malt, R.A. (1986). Augmentation of 1,2 dimethylhydrazine-induced colon cancer by experimental colitis in mice role of dietary vitamin E. J. Natl Cancer Inst. 76, 939-942. 

Manju, V. and N al i n i, N. (2005) Chemopreventive efficacy of ginger, a naturally occurring anti carcinogen during the initiation, post-initiation stages of 1,2-dimethylhydrazine induced colon cancer. Clinica Chimica Acta 358(1-2), 60-67. 

Dillehay, D.L., Webb, S.K., Schmelz, E.M., Merrill, A.H. Jr. 1994. Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J. Nutr. 124, 615-620. 

Kingsnorth AN, LaMuraglia GM, Ross JS, et al. 1986. Vanadate supplements and 1,2-dimethylhydrazine induced colon cancer in mice Increased thymidine incorporation without enhanced carcinogenesis. Br J Cancer 53 683-686. 

Sumiyoshi H, Wargovich MJ. Ghemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by natural-occurring organosulfur compounds. Cancer Res 1990 50 5084-5087. 

Influence Of Bran On Dimethylhydrazine-Induced Colon Cancer In Rats... 

Thorup I, Meyer 0, Kristiansen E. 1992. Effect of a dietary fiber (beet fiber) on dimethylhydrazine-induced colon cancer in Wistar rats. Nutr Cancer 17 251-261. 

Jacobs MM, Forst CF, Beams FA. 1981. Biochemical and clinical effects of selenium on dimethylhydrazine-induced colon cancer in rats. Cancer Res 41 4458-4-465. 

Craven PA, DeRubertis FR (1992) Alterations in protein kinase C in 1,2-dimethylhydrazine induced colonic carcinogenesis. Cancer Res 52 2216-2221... 

Bolognesi, C. Boffa, L.C. (1986) Correlation between incidence of 1,2-dimethylhydrazine-induced colon carcinomas and DNA damage in six genetically different mouse strains. Cancer Lett., 30, 91-95... 

Deschner, E.E., Long, EC. Hakissian, M. (1988) Susceptibility to 1,2-dimethylhydrazine-induced colonic tumors and epithelial cell proliferation characteristics of FI, F2, and reciprocal backcrosses derived from SWR/J and AKR/J parental mouse strains. Cancer, 61, 478-482... 

The Bowman-Birk inhibitor also blocks the transformation of C H/10T1/2 cells (18). This raises the speculation that BB may represent a direct acting nutritionally relevant anticarcinogen particularly in the case of colon cancer. In this regard it was recently reported that e-aminocaproic acid (a trypsin inhibitor) inhibits dimethylhydrazine-induced colon tumors in mice (22). 

Cook MG, McNamara P. 1980. Effect of dietary vitamin E on dimethylhydrazine-induced colonic tumors in mice. Cancer Res 40 1329-1331. 

Llor X, Jacoby RF, Teng BB, et al. 1991. K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors Effects of supplemental dietary calcium and vitamin D deficiency. Cancer Res 51 4305-4309. 

Jacobs MM. 1983. Selenium inhibition of 1,2-Dimethylhydrazine-induced colon carcinogenesis. Cancer Res 43 1646-1649. 

Nauss, K. M., Locniskar, M., and Newberne, P. M., 1983, Effect of alterations in the quality and quantity of dietary fat on 1,2-dimethylhydrazine-induced colon tumorigenesis in rats. Cancer Res. 43 4083. 

Zhi, H., Yamada, Y., Hirose, Y., Kato, K., Sheng, H., Zheng, Q., Oyama, T., Asano, N., Kuno, T., Hara, A., and Mori, H. 2007. Effect of 2-(carhoxyphenyl) retinamide and genistein on the formation of early lesions in 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Asian Pac J Cancer Prev 8,33-38. 

Locniskar, M., Nauss, K.M., Kauffman, P. Newbeme, PM. (1985) Comparison of immune status and 1,2-dimethylhydrazine induced tumorigenesis in Brown-Norway and Fischer rats. Emphasis on splenic and colonic lymphocyte function. Cancer Lett., 25, 311-323... 

Nauss, K.M., Locniskar. M., Pavlina, T. Newbeme, PM. (1984) Morphology and distribution of 1,2-dimethylhydrazine dihydrochloride-induced colon tumors and their relationship to gut-associated lymphoid tissue in the rat. J. natl Cancer Inst., 73, 915-924... 

Fiber was shown to inhibit carcinogenicity of 2-acetylaminofluorene more than thirty years ago (7,17). A recent review (18) has pointed out the lack of consistency in studies of fiber effects on experimental colon carcinogenesis. Investigators use different strains of rat, stock or semipurified diets, and different carcinogens administered orally, subcutaneously or intrarec-tally (Table v). Ward et al. (19) found cellulose to have no effect on the carcinogenicity of azoxymethane (AOM) in male Fisher rats fed a semipurified diet. Freeman et al. (20), on the other hand, found cellulose to protect male Wistar rats from colon cancer induced by subcutaneous injection of 1,2-dimethylhydrazine (DMH). 

Chester JR, Gaissert HA, Ross JS, et al. 1989. Colonic cancer induced by 1,2-dimethylhydrazine Promotion by experimental colitis. Br J Cancer 59 704-705. 

Various organic sulfides present in Allium have been found to have anticar-cinogenic activity. For example, allyl sulfide, a constituent of garlic oil, inhibited colon cancer in mice exposed to 1,2-dimethylhydrazine, and allyl methyl trisulfide, allyl methyl disulfide, aUyl trisulfide, and allyl sulfide all inhibited benzo[a]pyrene-induced neoplasma of the forestomach and lung in female mice (55). Lam et al. (Chapter 22) investigated the ability of 2-n-butyl thiophene, a constituent of roast beef aroma, to inhibit chemically induced carcinogenesis in three different tumor systems. This compound was found to be effective in the forestomach, lung, and colon models. 

Deschner, E. E., Florence, C. L., Hakissian, M., and Hermann, S. L., 1983, Differential susceptibility of AKR, C57BL/6J and CFl mice to 1,2-dimethylhydrazine induced tumor formation predicted by proliferative characteristics of colonic epithelial cells, J. Natl. Cancer Inst. 70 279. 

Freeman, H. J., Spiller, G. A., and Kim, Y. S., 1978, A double blind study on the effect of purified cellulose dietary fiber on 1,2-dimethylhydrazine induced rat colonic neoplasia. Cancer Res. 38 2912. 

Maskens, A. P., 1976, Histogenesis and growth pattern of 1,2-dimethylhydrazine-induced rat colon adenocarcinoma, Cancer Res. 316 1585. 

Cameron, I.L., Ord, V.A., Hunter, K.E., Padilla, G.M. Heitman, D.W. (1989) Suppression of a carcinogen (1,2-dimethylhydrazine dihydrochloride)-induced increase in mitotic activity in the colonic crypts of rats by addition of dietary cellulose. Cancer Res., 49, 991-995... 

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