Prebiotics colon cancer

Pool-Zobel, B., Van Loo, J., Rowland, L., and Roberfroid, M.B., Experimental evidence on the potential of prebiotic fructans to reduce the risk of colon cancer, Br. J. Nutr., 87, S273-S281, 2002. 

Prebiotic fiber in fruits is most easily associated with pulp—the fleshy, juicy part of a fruit—as opposed to its edible skin or seed coats which provide insoluble fiber. Prebiotic fiber provides diversified health benefits supporting advantageous intestinal bacteria and immune functions, all of which help deter both the onset of colon cancer and high blood cholesterol levels. 

In addition, a wide range of studies in rodent models on the effect of dietary prebiotics on cancer pathogenesis has consistently demonstrated a reduction in colonocyte DNA damage, aberrant crypt foci in the colon, nttmber of tumors per animal, size and growth rate of tumors, mean sttrvival time, and increase in life span (Pierre et al.,... 

Frtrthermore, in all animal studies where mixtures of probiotics and prebiotics were examined, the effect of the combination was greater than the sttm of the two separately, suggesting a synergistic effect of symbiotic compotmds. Based on these studies, considerable attention is being paid to dietary components that can influence the coloitic microflora as well as supplemental probiotics as strategies for colon cancer prevention. 

Pool-Zobel B,Van Loo J, Rowland 1, Roberfroid MB. Experimental evidences on the potential of prebiotic fractans to reduce the risk of colon cancer. BrJ Nutr 2002 87(Suppl. 2) S273—81. 

Reddy BS. Possible mechanisms by which pro- and prebiotics influence colon carcinogenesis and tumor growth. / Nutr. 1999 129 1478S—1482S. Rafter J, Bennett M, Caderni G, et al. Dietary sjmbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr. 2007 85 488-496. 

Commane DM, Short CT, Silvi S, Cresci A, Hughes RM, Rowland IR. Effects of fermentation products of pro- and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer. 2005 51 102-109. 

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