Colon cancer curcumin

It has been known since the early 1950s that turmeric had strong antioxidant effects with curcumin being the major compound responsible followed by demethoxycurcumin and bisdemethoxycurcumin. All three inhibit lipid peroxidation and have a positive anti-oxidant effect for hemolysis and lipid peroxidation in mouse erythrocytes.11 Curry pills containing turmeric are being marketed as a prevention for colon cancer.29... 

Chen A, Xu J, Johnson AC. 2006. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene 25 278-287. 

Collett GP, Campbell FC. 2004. Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Carcinogenesis 25 2183-2189. 

Du B, Jiang L, Xia Q, Zhong L. 2006. Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy 1 23-28. 

Moussavi M, Assi K, Gomez-Munoz A, Salh B. 2006. Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. Carcinogenesis 27 1636-1644. 

Patel BB, Sengupta R, Qazi S, Vachhani H, Yu Y, Rishi AK, Majumdar AP. 2008. Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Int J Cancer 2 267-273. 

Rashmi R, Kumar S, Karunagaran D. 2005. Human colon cancer cells lacking Bax resist curcumin-induced apoptosis and Bax requirement is dispensable with ectopic expression of Smac or downregulation of Bcl-XL. Carcinogenesis 26 713-723. 

Rashmi R, Kumar S, Karunagaran D. 2004a. Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. Carcinogenesis 25 1867-1877. 

Rashmi R, Santhosh Kumar TR, Karunagaran D. 2003. Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases. FEBS Lett 538 19-24. 

Reddy S, Rishi AK, Xu H, Levi E, Sarkar FH, Majumdar AP. 2006. Mechanisms of curcumin- and EGF-receptor related protein (ERRP)-dependent growth inhibition of colon cancer cells. Nutr Cancer 55 185-194. 

Shim JS, Lee J, Park HJ, Park SJ, Kwon HJ. 2004. A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2 + /calmodulin function. Chem Biol 11 1455-1463. 

Su CC, Chen GW, Lin JG, Wu LT, Chung JG. 2006. Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. Anticancer Res 26 1281-1288. 

Wang X, Wang Q, Ives KL, Evers BM. 2006a. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res 12 5346-5355. 

Kawamori,T. Lubet, R., Vernon, E.S., Kell off, C.J., Kaskey, R.B., Rao,V.R. and Reddy, B.S.(1 999) Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Research 59, 597-601. 

Cheng, Y., Kozubek, A., Ohlsson, L., Sternby, B., and Duan, R.D., Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells, Planta Med, 73 (2007) 725-730. 

Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. Modulation of apoptosis by sulindac, curcumin, phenylethyL3-methylcaffeate, and 6-phenylhexyl isothiocyanate apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res 1997 57 1301-1305. 

Helicobacter pylori is a Group 1 oareinogen and is assoeiated with the development of gastric and colon cancer. Mahady et al. have demonstrated that eureumin inhibits the growth of H. pylori eagA+ mouse strains in vitro, and this may be one of the mechanisms by which curcumin exerts its ehemopreventive effeets. 

Jaiswal, A.S., Marlow, B.P., Gupta, N., and Narayan, S., Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuyhnethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene, 21 (55), 8414-8427,2002. 

---