Colon cancer diarrhea

Combination therapy Nausea, vomiting, diarrhea, in patients with Dukes stomatitis, anorexia stage C colon cancer... 

In phase I clinical trials 47 patients, all of whom had previously failed standard treatments for solid tumors, received the drug in the UK, Italy, and Switzerland on three different schedules.123,124 Dose-limiting toxicities have been defined as bone marrow depression and diarrhea. The latter is treatable with loperamide. Signs of biological activity were seen. Notably one patient with metastatic pancreatic cancer showed a partial response (for 4 months) and two further patients, one with metastatic melanoma and one with bronchoalveolar carcinoma, also showed partial responses. In a phase I trial in combination with 5-FU, a partial response in breast cancer was observed.125 Furthermore, a reduction in tumor marker levels was observed in two patients, one with ovarian cancer, and one with colon cancer. Phase II studies have shown partial responses in cisplatin-resistant ovarian and nonsmall-cell lung cancer.126,127 The indications are that the profile of clinical activity is different and complementary to the mononuclear platinum agents. 

A 60-year-old woman is being treated for metastatic colon cancer with her first course of irinotecan combined with fluorouracil (5-FU) and leucovorin. One hour after completing the irinotecan infusion, she complains of diaphoresis, crampy abdominal pain, and diarrhea. 

Hematologic An 88-year-old woman with glucose-6-phosphate dehydrogenase (G6PD) deflciency developed an acute hemolytic anemia soon after the use of intravenous ciprofloxacin 500mg/day for fever and diarrhea after chemotherapy for colon cancer [25 ]. She had shortness of breath, cyanosis, and a fall in hemoglobin from 11.1 to 6.4 g/dl. 

Palmer, R. H., 1979, Bile acid heterogeneity and the gastrointestinal epithelium From diarrhea to colon cancer, J. Lab. Clin. Med. 94 655. 

Prolonged diarrhea (ulcerative colitis, Crohn s disease, or cancer of the colon) Renal... 

Hicks RM, Ismail MM, Walters CL, Beecham PT, Rabie MF, El Alamy MA (1982) Association of bacteriuiia and urinary nitrosamine formation with Schistosoma haematobium infection in the Qalyub area of Egypt. Trans R Soc Trop Med Hyg 76 519-527 Izquierdo J, Antunez I, Calderon MT, Perez Giraldo C, Munoz Sanz A (1988) Diarrhea caused by Cryptosporidium and colonic neoplasia. Rev din Esp 182 393-394 Khurana S, Dubey ML, MaUa N (2005) Association of parasitic infections and cancers. Indian J Med Microbiol 23 74—79... 

Disturbances in the electrolyte and fluid balance of the body which are tissociated with (a) persistent vomiting due to an obstructive growth, (b) vomiting due to pressure from a brain tumor, (c) diarrhea induced by hormone secreting cancers and cancer of the colon, (d) cancers which disrupt the reletise of antidiuretic hormone from the posterior pituitary, and (e) tumors causing excessive secretion of corticotropin or corticosteroid which results in hyperadrenalism. 

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