Cell lines colon cancer

AVIVI-GREEN c, PLOAK-CHARCON s, MADAR z, SCHWARTZ B (2002) Different molecule events account for butyrate-induced apoptosis in tiw human colon cancer cell line. J. Nutr. 132 1812-18. 

GAMET L, DAViAUD D, DENis-POUXViEL 0, REMESY 0, MURAT J 0 (1992) Effects of shoit-chain fatty acids on growth and differentiation of the human colon-cancer cell line HT29. Int J Cancer. 52 286-9. 

Another human colonic cancer cell line is T84 this develops monolayers of high TER ( 1000 Q cm2) when grown on permeable supports, but cells are not well differentiated and have been described as resembling a colonic crypt cell phenotype. Hence, these cells have been used mainly in studies of epithelial ion transport and are generally not considered to be adequate for drug transport studies, particularly with respect to carrier-mediated processes [10, 79, 82-84]. 

K. Schlottman, F. P. Wachs, R. C. Krieg, F. Kullmann, J. Scholmerich and G. Rogler, Characterization of bile salt-induced apoptosis in colon cancer cell lines. Cancer Res., 2000, 60(15), 4270. 

S. Lechner, U. Muller-Ladner, K. Schlottmann, B. Jung, M. McClelland, J. Ruschoff, J. Welsh, J. Scholmerich and F. Kullmann, Bile acids mimic oxidative stress induced up-regulation of thioredoxin reductase in colon cancer cell lines, Carcinogenesis, 2002, 23(8), 1281. 

Nakano K, Mizuno T, Sowa Y, Orita T, Yoshino T, Okuyama Y, Fujita T, Ohtani-Fujita N, Matsukawa Y, Tokino T, Yamagishi H, Oka T, Nomura H, Sakai T. (1997) Butyrate activates the WAFl/Cipl gene promoter through Spl sites in a p53-negative human colon cancer cell line. J Biol Chem 212 22199-22206. 

The cancer cell lines SW480 and SW620 are two colon cancer cell lines that were obtained from the same patient the SW480 cell line was obtained from the primary tumor, and the SW620 cell line was obtained from a metastatic site. (Adapted from Seeram et al., 2004)... 

Goldstein DR, Cacace AM, Weinstein IB (1995) Overexpression of protein kinase C pi in the SW480 colon cancer cell line causes growth suppression. Carcinogenesis 16 1121-1126... 

Wadler S, Wersto R, Weinberg V, et al. Interaction of fluorouracil and interferon in human colon cancer cell lines Cytotoxic and cytokinetic effects. Cancer Res 1990 50 5735-5739. 

Grem, JL, Mulcahy T, Miller EM, et al. Interaction of deoxyuridine with fluorouracil and dipyridamole in a human colon cancer cell line. Biochem Pharmacol 1989 38 51-59. 

Ogier-Denis E, Couvineau A, Maoret JJ, Houri JJ, Bauvy C, De Stefanis D, Isidore C, Laburthe M, Codogno P (1995) A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29. J Biol Chem 270 13-16... 

Posner and coworkers have prepared a series of semi-synthetic and synthetic ether and ester-linked dimers that were found to have potent anti-proliferative and antitumour activities in vitro162. Some of these trioxane dimers were found to be as antiproliferative as calcitriol, the hormonally active form of vitamin D, which is used to treat psoriasis, a skin disorder characterized by uncontrolled cell proliferation. Of the semi synthetic dimers, a polyethylene glycol-linked dimer 107, with /3-stereochemistry at both of the lactol acetal positions, was found to be very anti-proliferative and showed activity against leukaemia and colon cancer cell lines in the National Cancer Institute (NCI), USA 60-cell line assay. 

Compound 2 inhibited murine and human bone marrow cell colony formation with and ID50 of 0.1-1 pg/ml, with complete inhibition occurring at 10-100 pg/ml. It was found to be more potent than vinblastine or taxol, with an IC50 of 0.23 nM against human ovarian cancer and colon cancer cell lines. Furthermore, dolastatin 10 was shown to be powerfully effective at binding to tubulin, inhibiting polymerization and it also non-competitively inhibits the binding of vinca alkaloids to tubulin,... 

Wolter F, Akoglu B, Clausnitzer A, Stein J. 2001. Downregulation of the cyclin D1 / Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. JNutr 131 2197-2203. 

Du B, Jiang L, Xia Q, Zhong L. 2006. Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29. Chemotherapy 1 23-28. 

Recently, Palmer et al., working with human colon cancer cell lines, reported dramatic up-regulation of kallikreins 6 and 10 by la, 25-dihydroxyvitamin D3 [158]. This finding raises the possibility that some kallikreins could be regulated by a multitude of nuclear receptors. 

It possessed cytotoxicity for six cell lines (IC50 l 100pg/mL) and antitumor effects on human nasopharyngeal cancer (CNE2, SUNE-1) and human liver cancer (BEL-7402) in nude mice. Recently artesunate has been analyzed for its antitumor activity against 55 cell lines.It was most active against leukemia and colon cancer cell lines. It is notable that no CEM leukemia sublines, which are resistant to either doxorubicin, vincristine, methotrexate, or hydroxyurea, showed cross resistance to artesunate. 

Several compounds derived from these libraries were identified as Hsp70 modulators and were further evaluated in cell proliferation assays such as the SK-BR-3 and MCF-7 breast cancer cell lines and the HT29 colon cancer cell line (Fig. 6) [26]. Compounds 22-24 were potent against all three cell lines. The dihydro-pyrimidinone libraries were also tested for replication inhibition of the malarial parasite, Plasmodium falciparum, where Hsp70 chaperones are believed to play an important role in the parasite s homeostasis [24]. Nine compounds that inhibit replication of the parasite were identified. Among them, compounds 25 and 26 were the most potent (Fig. 7) and were prepared by direct couplings of dihydropyrimidone acids 19 with a pyrrolo amine. 

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