Colorectal cancers

Color development Colorectal cancer Colored contact lenses Colored pigments Colorfastness Color filters... [Pg.240]

Colorectal Cancer. Colorectal cancer occurs frequently in the UK population but is historically rare in Asia. Rates in Japan have, however, increased rapidly in recent years.Interestingly, there appears to be an association between oestrogen exposure and colon cancer risk has been shown to increase in women with increasing age of first live birth, and to decrease with increasing parity (number of children). In addition, many colon tumours express sex hormone receptors, and this is thought to play a part in development of the tumours. "... [Pg.126]

Since COX-2 is overexpressed in tumour cells, such as those of colorectal cancer, it was anticipated that selective COX-2 inhibitors may inhibit tumour growth. [Pg.404]

However, already in an early clinical trial, rofecoxib was found to produce four times the number of myocardial infarctions than its comparator drug, naproxen. A subsequent trial of rofecoxib compared to placebo in colorectal cancer prevention demonstrated, after 18 months of study, that a greater number of myocardial infarctions occulted in the rofecoxib group. In 2004 the manufacturers of rofecoxib withdrew the diug from the market. A similar study of celecoxib compared to placebo in cancer prevention, showed that celecoxib also increased the risk of cardiovascular embolisms [3]. [Pg.406]

Cetuximab Anti-EGFR Colorectal cancer, Head and Neck cancers... [Pg.603]

Bevacizumab (Avastin ) Roche mAb VEGFR Metastatic colorectal cancer... [Pg.1193]

ISS Agonist Colorectal cancer Phase I clinical trials... [Pg.1211]

ADCC. Cetuximab is approved for treatment of metastatic colorectal cancer (CRC) and squamous cell carcinoma of the head and neck (SCCHN). Interestingly, an adverse event, acneiform rash seems to correlate with a better response to cetuximab, while there is no such correlation with expression levels of EGFR assessed by immunohistochemistry. Further side effects are rare infusion reactions and hypomagnesia. Two other anti-EGFR antibodies approved for clinical use are the fully human antibody panitumumab (Vectibix)... [Pg.1255]

The clinical trial that resulted in FDA approval of bevacizumab (February 2004) was a randomized, double-blind, phase III study in which bevacizumab was administered in combination with bolus-IFL (irinotecan, 5FU, leucovorin) chemotherapy as first-line therapy for previously untreated metastatic colorectal cancer [3]. Median survival was increased from 15.6 months in the bolus-IFL + placebo arm to 20.3 months in the bolus-IFL + bevacizumab arm. [Pg.1271]

Hurwitz H, Fehrenbacher L, Novotny W et al (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovor-in for metastatic colorectal cancer. N Engl J Med 350 2335-2342... [Pg.1272]

Breast cancer (WNT 1, WNT5a) Breast cancer Invasive breast cancer Liver cancer Colorectal cancer (spontaneous)... [Pg.1320]

Lung (Fz9) Multiple myeloma Colorectal cancer Skin cancer Leukemia... [Pg.1320]

Liver (Fz7) Colorectal cancer Liver cancer Gastrointestinal cancer... [Pg.1320]

MA J, STAMPFER M J, GIOVANNUCCI E, ARTIGAS C, HUNTER D J, FUCHS C, WILLETT W C, SELHUB J, HENNEKENS c H and ROZEN R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer . Cancer Res, 57, 1098-102. [Pg.42]

The involvement of tobacco smoke carcinogens in the aetiology of lung cancer is conclusively established, but the role of specific chemical carcinogens as inducers of colorectal cancer is much less clear. Mutagenic pyrolysis products derived from cooked food have come under suspicion as possible... [Pg.53]

LUND E K, SMITH T K, CLARKE R G and JOHNSON I T (2001) Cell death in the colorectal cancer cell line HT29 in response to glucosinolate metabolites , J i FoodAgric, 81 959-61. [Pg.64]

Green tea consumption and the risk of pancreatic and colorectal cancers , Int J Cancer, 70, 255-8. [Pg.153]

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