Nifedipine, inhibition

In vitro nifedipine inhibits proliferation of colon cancer cells with a DNA mismatch repair defect that are resistant to 5-fluorouracil. Whether this also... 

Ca44 channel-blockers Nifedipine Inhibits voltage-dependent L-type Ca44 channels. 

Verapamil, diltiazem, and perhaps nicardipine (but not nifedipine) inhibit hepatic drug-metabolizing enzymes. Metabolism of diltiazem, nifedipine, verapamil, and probably other calcium channel blockers subject to induction and inhibition. 

Bischoff, A., Finger, J., and Michel, M. C. (2001). Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. Naunyn. Schmiedebergs Arch. Pharmacol. 364(2), 179-182. 

CALCIUM CHANNEL BLOCKERS CIMETIDINE t levels of calcium channel blockers, especially diltiazem and nifedipine Inhibition of CYP3A isoform-mediated metabolism Monitor BP at least weekly until stable watch for i BP. Consider reducing the dose of diltiazem and nifedipine by up to 50%... 

In order to determine if ( )-ka n had calcium channel blocking properties, experiments using nifedipine were performed (Table 6.1). Nifedipine inhibited contractions evoked by BAY K 8644 and by substance P. Even at high concentrations (1 XM), nifedipine failed to completely block contractions evolsd by carbachol (10 XM). After pre-incubation with 1 XM nifedipine, carbachol (lOjlM) evoked 18.2+4.3% contraction of pre-incubation control value. The remaining response was completely abolished by high concentrations of ( )-kavain (400 lM). 

Differences exist in the ability of calcium channel blockers to inhibit contractions induced by high potassium ion (K +) depolarization compared with contractions resulting from the interaction of agonists with their receptor sites. In the majority of tissues, K + -invoked responses are blocked to a greater extent than responses to noradrenaline (NA) (norepinephrine) [22-24, 33]. However, in the rat portal vein, both diltiazem and nifedipine inhibit contractions induced by NA significantly more than those induced by K+ [29]. Furthermore, in rabbit mesenteric resistance vessels, Ca2+ influx stimulated by NA is more sensitive to inhibition by diltiazem than is Ca2+ influx stimulated by K+ [22],... 

Szab6, C., Mitchell, J. A., Gross, S. S., Thiemermann, C., and Vane, J. R. (1993e). Nifedipine inhibits endotoxin-mediated nitric oxide synthase induction. J. Pharmacol. Exp. Ther. 256, 674-680. 

Calcium Channel Blockers - The therapeutic value of calcium channel blockers for the treatment of asthma remains unclear however, they are Important invest atlve tools for the study of airway smooth muscle and cell secretion. Nifedipine inhibited calcium lonophore-induced... 

LeeKS, LeeEW. Ionic mechanism of ibutilide in human atrium evidence for a dn -induced Na current tiirough a nifedipine inhibited inward channel. J Pharmacol Exp Ther (1998) 286,... 

Figure 3 K+ channels are the effectors in the O2 constriction of the DA. (a) A freshly isolated human DA ring, studied in hypoxia to mimic in utero conditions, constricts to 4-aminopyridine and normoxia. The L-lype Ca " channel blocker nifedipine inhibits the constriction to 4-aminopyridine suggesting that constriction occurred because of 4-aminopyridine-induced depolarization, increased opening of the L-lype Ca " chaimels, and an influx of Ca +. (From Ref. 107.) (b) Patch-clamp studies of isolated rabbit DASMC show an 02-induced inhibition of K" " current, similar to that achieved by 4-aminopyridine. (From Ref 12.)...

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