Cancer cell inhibition

M5250 Melatonin Enhances apoptic death of cancer cells inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action. 

Resveratrol In estrogen-responsive MCF-7 human breast cancer cells Inhibiting cell proliferation by interfering with an estrogen receptor-a (ERa)-associated PI3K pathway [100]... 

S. Lu, H. Wang, Y. Sheng, M. Liu, and P. Chen, Molecular binding of self-assembling peptide EAK16-II with anticancer agent EPT and its implication in cancer cell inhibition, y. Control Release, 160 (2012)33-40. 

Empirical C18H39NO3 Properties Wh. powd. m.w. 317.51 Toxicology Potentially harmful by inh., ing. potential eye/skin irritant Hazardous Decomp. Prods. CO, CO2 Uses Preservative, antimicrobial in deodorants, skin care antimicrobial in acne preps. regulatory llpid, antibacterial barrier in the skin anti-inflammatory induction of apoptotic cell death In human cancer cells inhibits cell growth of Saccharomyces cerevisiae by inhibiting tryptophan import precursor of ceramides... 

StUbenes such as resveratrol, combretastatin, and pterostUbene and their analogues possess a wide spectrum of biological activities. These compounds have been proved to be antioxidant reagents that cause cell apoptosis, suppress growing cancer cells, inhibit and activate spedfic enzymes, effed the animal aging and metabolisms... 

Choi, S.H., Kim, H.R., Kim, H.J., Lee, I.S., Kozukue, N., Levin, C.E., and Friedman, N. 2011. Free amino acid and phenolic contents and antioxidative and cancer cell-inhibiting activities of extracts of 11 greenhouse-grown tomato varieties and 13 tomato-based foods. J. Agric. Food Chem. 59 12801-12814. 

Park CC, Zhang H, Pallavicini M et al (2006) Betal integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 66 1526-1535 Parsons JT (2003) Focal adhesion kinase the first ten years. J Cell Sci 116 1409-1416... 

Enediynes hold substantial promise as anti cancer drugs because of their potency and selectivity Not only do they inhibit cell growth they have a greater tendency to kill cancer cells than they do normal cells The mechanism by which enediynes act involves novel chemistry unique to the C C—C=C—C C unit which leads to a species that cleaves DNA and halts tumor growth... 

WS-7528 [132147-69-4][VI] a nonsteroidal estrogen, is an isoflavone which has been isolated from Streptomjces sp. No. 7528 and is an estrogen agonist. It inhibits [3ff]-estradiol binding to its receptor in rat uterine cytosol at an inhibitor for 50% of the rats tested (IC q) concentration of 5.7 nM. It also induces the growth of estrogen-dependent human breast cancer cell line MCE-7 (7). 

It is important to note that diet is a complex mixture that contain compounds with varying activity. Chemical stimulators of colon cancer growth include bile acids, 1,2-diglycerides and prostaglandins which stem from consumption of fat. In contrast, fruits and vegetables contain substances such as carotenoids, flavonoids and fibre, which may inhibit cancer cell growth, and the risk of colon cancer appears to be mirrored by the ratio of plant sterols to cholesterol in the... 

Kidney cells grown in culture with liver cells seek out and make contact with other kidney cells and avoid contact with liver cells. Cells grown in culture grow freely until they make contact with one another, at which point growth stops, a phenomenon well known as contact inhibition. One important characteristic of cancerous cells is the loss of contact inhibition. 

Besides direct apoptosis effectors, there are a number of other diugs which influence the above explained apoptosis pathways more indirectly. This class of diugs includes molecules which inhibit survival pathways like e.g. the Ras/Raf kinase pathway, the NF-kB pathway and many others. Also inhibitors of survival cytokines which are sometimes produced by cancer cells in an autocrine fashion can render cells susceptible to apoptosis and, hence, effective cancer therapy. These include, but are not limited to, ligands for dependence receptors and cytokines like e.g. interleukin-4. 

In vitro nifedipine inhibits proliferation of colon cancer cells with a DNA mismatch repair defect that are resistant to 5-fluorouracil. Whether this also... 

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