Colon cancer heme-iron

Baradat, M., 1. Jonanin, S. DaUeau, S. Tache, M. Gieules et al. 2011.4-Hydroxy-2(E)-nonenal metabohsm differs in Apc(4-/+) cells and in Apc(Min/+) cells It may explain colon cancer promotion by heme iron. ChanResJj i ol 24 1984—1993. 

Here, we demonstrate that SM(16 0) was strongly expressed in the cancerous area. Previous studies reported that in colon cancer, the cancerous cells contain elevated amounts of total phospholipids [85], and in addition, the phospholipid composition of the cellular membrane is altered [85,86] even between cancer cell types, that is, metastases and nonmetastatic cancer [86]. Brasitus et al. studied a relationship between the malignancy and altered lipid composition of the colon cancer, and reported significant accumulation of SM, consistent with the presented result [87]. On the other hand, heme B consists of an iron atom and porphyrin, and is known as a prosthetic group in hemoglobin, which is a protein in erythrocytes. Presented results indicate the difference between the blood-rich organ liver and the ischemic metastatic colon cancer [88,89]. 

Sawa, T., Akaike, T., Kida, K., Fukushima, Y., Takagi, K. and Maeda, H. 1998. Lipid peroxyl radicals from oxidised oils and heme iron Implication of high fat diet in colon carcinogenesis. Cancer Epidemiol. Biomark. Prev. 1 1007-1012. 

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