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Cells cycle

The last part of this account will be devoted to protein kinases and protein phosphatases and some recent results we have obtained for them. Protein kinases and phosphatases are signaling biomolecules that control the level of phosphorylation and dephosphorylation of tyrosine, serine or threonine residues in other proteins, and by this means regulate a variety of fundamental cellular processes including cell growth and proliferation, cell cycle and cytoskeletal integrity. [Pg.190]

Product formation kinetics in mammalian cells has been studied extensively for hybridomas. Most monoclonal antibodies are produced at an enhanced rate during the Gq phase of the cell cycle (8—10). A model for antibody production based on this cell cycle dependence and traditional Monod kinetics for cell growth has been proposed (11). However, it is not clear if this cell cycle dependence carries over to recombinant CHO cells. In fact it has been reported that dihydrofolate reductase, the gene for which is co-amplified with the gene for the recombinant protein in CHO cells, synthesis is associated with the S phase of the cell cycle (12). Hence it is possible that the product formation kinetics in recombinant CHO cells is different from that of hybridomas. [Pg.230]

Antimetabolites may be further classified as inhibitors of pyrimidine, purine, or glutamine metaboHsm. The compounds are cell cycle dependent. [Pg.435]

Conformational changes in a protein kinase are important for cell cycle regulation... [Pg.105]

Jackow.ski, S., 1996. Cell cycle regnlation of membrane pho.spholipid metabolism, yowraa/ of Biological Chemistry 271 20219-20222. [Pg.850]

Figure 3. Charge and discharge curves of an Li/Li[Li0jMn, 9]04 cell cycled at voltages between 3.0 and 4.4V at a rate of 0.1 mAcnT2 at 30 °C. To describe the composition of an Li-Mn-O ternary phase a defect-spinel formulation was assumed. Figure 3. Charge and discharge curves of an Li/Li[Li0jMn, 9]04 cell cycled at voltages between 3.0 and 4.4V at a rate of 0.1 mAcnT2 at 30 °C. To describe the composition of an Li-Mn-O ternary phase a defect-spinel formulation was assumed.
During the 1990s, lithium polymer cells have been scaled up to a size of 10 Wh, and assessment of their performance of continues. Test cells show a 1000-fold scale-up to have little effect on cell cycling... [Pg.501]

Dacarbazine is activated by photodecomposition (chemical breakdown caused by radiant energy) and by enzymatic N-demethylation. Formation of a methyl carbonium ion results in methylation of DNA and RNA and inhibition of nucleic acid and protein synthesis. Cells in all phases of the cell cycle are susceptible to dacarbazine. The drug is not appreciably protein bound, and it does not enter the central nervous system. [Pg.56]

The ankyrin repeat motif is one of the most common protein-protein interaction domains. Ankyrin repeats are modules of about 33 amino acids repeated in tandem. They are found in a large number of proteins with diverse cellular functions such as transcriptional regulators, signal transducers, cell-cycle regulators, and cytoskeletal proteins. [Pg.90]

Antimetabolites interfere with normal metabolic pathways. They can be grouped into folate antagonists and analogues of purine or pyrimidine bases. Their action is limited to the S-phase of the cell cycle and therefore they target a smaller fraction of cells as compared with alkylating agents. [Pg.154]

In general, the mechanisms of action are not cell cycle specific, although some members of the class show greatest activity at certain phases of the cell cycle, such as S-phase (anthracyclins, mitoxantrone), Gl- and early S-phases (mitomycin C) and G2- and M-phases (bleomycins). [Pg.155]

Vinca alkaloids (vincristine, vinblastine, vindesine) are derived from the periwinkle plant (Vinca rosea), they bind to tubulin and inhibit its polymerization into microtubules and spindle formation, thus producing metaphase arrest. They are cell cycle specific and interfere also with other cellular activities that involve microtubules, such as leukocyte phagocytosis, chemotaxis, and axonal transport in neurons. Vincristine is mainly neurotoxic and mildly hematotoxic, vinblastine is myelosuppressive with veiy low neurotoxicity whereas vindesine has both, moderate myelotoxicity and neurotoxicity. [Pg.155]

Estrogen receptor Transcriptional regulator Inhibition of cell-cycle progression... [Pg.187]


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Apigenin cell cycle arrest induced

Biotin cell cycle

Biotin in Regulation of the Cell Cycle

Bisindolymaleimides cell-cycle checkpoint inhibition

Calvin-Benson cycle cells

Cancer cell cycle

Catalytic cycles enzymes and cell cycle

Cell Cycle Control

Cell Cycle Control of DNA Replication

Cell Cycle Information Flow Stages and General Biochemical Events

Cell cycle 324 INDEX

Cell cycle Mitosis

Cell cycle Mitotic phase

Cell cycle activity

Cell cycle analysis

Cell cycle analysis by flow cytometry

Cell cycle analysis intracellular proteins

Cell cycle analysis kinetics

Cell cycle and growth

Cell cycle apoptosis and

Cell cycle arrest

Cell cycle automaton

Cell cycle cancer defects

Cell cycle checkpoint control

Cell cycle checkpoints

Cell cycle components

Cell cycle cyclin

Cell cycle cyclin-dependent kinase

Cell cycle cyclin-dependent kinase inhibitors

Cell cycle enzyme

Cell cycle enzyme formation

Cell cycle enzyme synthesis

Cell cycle events

Cell cycle events regulator

Cell cycle exit timing

Cell cycle figure

Cell cycle gene

Cell cycle growth linked

Cell cycle hormonal effects

Cell cycle inhibitors

Cell cycle kinases, regulation

Cell cycle kinetics

Cell cycle machinery

Cell cycle mitotic spindle-targeting drugs

Cell cycle modulation studies

Cell cycle modulators

Cell cycle oscillations

Cell cycle overview

Cell cycle pattern linked

Cell cycle phases

Cell cycle phytochemical modulation

Cell cycle progression

Cell cycle progression, regulator

Cell cycle protein modulation

Cell cycle protein modulation ligand receptor binding

Cell cycle protein modulation signaling regulation

Cell cycle redistribution

Cell cycle regulation

Cell cycle retinoblastoma protein

Cell cycle spindle checkpoint

Cell cycle stage

Cell cycle sulforaphane-induced arrest

Cell cycle taxane effects

Cell cycle temporal control

Cell cycle terminology

Cell cycle therapies

Cell cycle transcriptional repression/genes

Cell cycle transition, in Xenopus

Cell cycle types

Cell cycle, eukaryotic

Cell cycle, in cancer cells

Cell cycle, models

Cell cycle, phenolics effect

Cell cycle, tocotrienols

Cell cycle-nonspecific drug

Cell cycle-specific drug

Cell cycles S phase

Cell cycles/kinases

Cell division cycle

Cell division cycle, Saccharomyces

Cell division cycle, Saccharomyces cerevisiae

Cell division cycles, stopping

Cell growth cycle

Cell membranes citric acid cycle

Cell redox cycling

Cell-cycle and Checkpoint Control

Cell-cycle control system

Cell-cycle delay

Cell-cycle dependent

Cell-cycle dependent drugs

Cell-cycle independent drugs

Cell-cycle inhibition

Cell-cycle perturbations

Cell-cycle regulatory proteins

Cell-cycle specific agent

Cell-cycle specificity

Cell-cycle specificity, cytotoxic drugs

Cell-cycle-nonspecific cytotoxic

Cell-cycle-related proteins

Cell-life cycle

Cells, Krebs cycle

Chemotherapy cell-cycle specificity

Combined Brayton-Rankine Cycle Fuel Cell Power Generation System

Cori cycle cells

Culture suspension, cytokinin, cell cycl

Cyclin , mitotic cell cycle

Cyclin cell cycle regulation

Cyclin-dependent kinase cell cycle regulation

Cyclin-dependent kinase inhibitors cell cycle regulation

Cyclins, mitotic cell cycle

Cytotoxic agents cell-cycle-nonspecific

Cytotoxic agents cell-cycle-specific

Drug action, cell cycle specificity

Embryonic cell cycles

Eukaryotes cell cycle

Eukaryotes cell life cycle

Feeding cycle cell culture

Fission yeast cell cycle

Flow cell-cycle analysis

Flow cytometry cell cycle analysis

Fuel Cell Rankine Cycle Arrangement

Fuel cell life cycle assessment

Function of pRb in the Cell Cycle

G2/M phase cell cycle

Genes controlling the cell cycle

Growth Factors, Oncogenes, and the Cell Cycle

HTC cell cycle

Histones synthesis during cell cycle

Hyaluronan and Induction of Cellular Cycles for Differentiated Cells

Hybrid cell cycle

Integrated Coal Gasification Fuel Cell Combined Cycle

Key elements of the Cell Cycle Apparatus

Life cycle assessment fuel cell materials

Life-cycle analysis of fuel cells

Living systems cell cycles

Lycopene cell cycle

M-phase of cell cycle

Meiotic cell cycle

Microtubule cell cycle-dependent

Mitotic cell cycle

Model cell cycle automaton

Mouse embryos, cell cycle regulation

New cell cycle

Phytochemicals cell cycle modulated

Plant cells glyoxylate cycle

Principles of Cell Cycle Control

Recycling and life cycle assessment of fuel cell materials

Regenerative Brayton Cycle Fuel Cell Power System

Regulation of cell cycling

Regulation of the Cell Cycle

Regulation of the Cell Cycle by Proteolysis

Relaxation oscillator cell cycle

Replication eukaryotic cell cycle

Retinal cycle of mammalian rod cells

Retinoblastoma Gene and the Cell Cycle

Retinoblastoma protein , cell cycle regulation

Rod cells of eye retinal cycle

Rules of the Cell Cycle Automaton

S-phase of cell cycle

Schizosaccharomyces pombe cell cycle

Solid oxide fuel cells combined cycle systems

Solid oxide fuel cells combined cycles

Somatic cell cycles

Synthesis, cell cycle

Tetrahymena cell cycle, synchronization

The cell cycle

The cell division cycle and its control

The eukaryotic cell cycle is driven by a biochemical oscillator

Thermodynamics long-cycled cells

Transferrin to cell cycle

Tumor suppressor genes cell cycle arrest

VitaminE, llOf cell cycle arrest

Work cycles living cells

Xenopus cell cycle transition

Yeast cell cycle

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