Cyclin-dependent kinase inhibitors cell cycle regulation

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Sielecki, T.M., Boylan, J.F., Benfield, P.A., Trainor, G.L. Cyclin-dependent kinase inhibitors useful targets in cell cycle regulation. Journal of Medicinal Chemistry 2000, 43, 1-18. 

Kleinschmidt MA, de Graaf P, van Teeffelen HA, Timmers HT. Cell cycle regulation by the PRMT 6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors. PLoS One. 2012 55 7978-87. 

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Cyclin-dependent kinases (CDKs) play a key role in regulating cell cycle machinery. This family of kinases requires association with a cyclin regulatory subunit for activity. Different CDK/cyclin pairs are active during each phase of the cell cycle. Negishi cross-coupling reactions were the key steps in the synthesis of [l,3,5]triazine-pyridine biheteroaryls 161 as a novel series of potent cyclin-dependent kinase inhibitors. ... 

Fisher, L., Endicott, J., and Meijer, L. (2003) Cyclin-dependent kinase inhibitors, in Cell Cycle Regulators as Therapeutic Targets, vol. 5 (eds L. Meijer, A. Jezequel, and M. Roberge), Life in Progress, Roscoff, France, pp. 235-248. 

Hengst, L., Dulic, V., Slingerland, J., Lees, E., and Reed, S. (1994). A cell cycle regulated inhibitor of cyclin-dependent kinases, Proc Natl Acad Sci USA 91, 5291-5295. 

The tumour suppressor p53 is a very versatile transcriptional regulator. Among the many genes controlled by p53 are cyclin genes, genes for an inhibitor of cyclin-dependent kinases, and the bax gene, which promotes apoptosis. This repertoire of genes controlled by p53 links this tumour suppressor to cell-cycle control and apoptosis (see Chapters 12 and 13). 

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