Cell cycle progression, regulator

Estrogen receptor Transcriptional regulator Inhibition of cell-cycle progression... 

Hong Y, Roy R, Ambros V 1998 Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegant. Development 125 3585—3597... 

Hensey C, Gautier J 1995 Regulation of cell cycle progression following DNA damage. Prog Cell Cycle Res 1 149-162... 

Moreover, we recently reported that lycopene was able to enhance the arrest of cell cycle progression induced by TAR in RAT-1 immortalized fibroblasts. TAR-exposed cells treated with lycopene showed a delay in cell cycle at the G0/G1 phase and a concomitant reduction in S phase. Such effects were accompanied by a dose-dependent decrease in cyclin Dl levels. On the other hand, fibroblasts treated with lycopene alone showed the same effects, although to a lower extent. The down-regulation of cyclin Dl observed in this study was dose-dependent and occurred at lycopene concentration achievable in vivo after carotenoid supplementation (Palozza et al., 2005b). 

Although further studies are needed to clarify the mechanism(s) of lycopene interference with cell signaling leading to down-regulation of cyclin Dl and ultimately to cell cycle arrest in both normal and tumor cells, these reports suggest that the reduction in cyclin Dl by lycopene treatment may be a key event in the ability of the carotenoid to arrest cell cycle progression. 

Palozza, P., Serini, S., Torsello, A. et al. 2002b. Regulation of cell cycle progression and apoptosis by beta-carotene in undifferentiated and differentiated HL-60 leukemia cells possible involvement of a redox mechanism. Int J Cancer 97 593-600. 

Kahl CR, Means AR (2003) Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev 24 719-736... 

Greenwald, R.J. et al., CTLA-4 regulates cell cycle progression during aprimary immune response, Eur. J. Immunol., 32, 366, 2002. 

Nebigil, C.G., Launay, J.M., Hickel, P., Tournois, C. and Maroteaux, L. (2000) 5-Hydroxytryptamine 2B receptor regulates cell-cycle progression cross-talk with tyrosine kinase pathways. Proceedings of the National Academy of Sciences of the United States of America, 97 (6), 2591-2596. 

The SCF and SCF-like complexes are multi-subunit RING-type E3s that represent the largest E3 family knotvn to date. This superfamily of E3s are involved in regulating cell-cycle progression, signal transduction pathways, transcriptional control, and multiple aspects of cell growth and development (reviewed in Ref. [50]). All members of this E3 superfamily contain two basic components, a member of the cullin protein family and a RING-domain protein. The cullin subumt serves as the... 

Ulpl S. cerevisiae lethal regulates cell cycle progression [39]... 

DNA vimses can regulate the activity of cellular acetyltransferases and to effect cell cycle progression in support of virus replication. Viral infection mediated... 

Cell cycle progression, apoptosis, DNA damage and DNA repair are cellular functions that are regulated by several mechanisms. One such important regulatory mechanism is posttranslational modification of histone and non-histone proteins. Myriad of reports have been shown that acetylation of non-histone proteins apart from histones, contributes in major to these processes. 

---