Cell cycle temporal control

The temporal control of cell cycle and cell fate in Caenorhabditis elegans... 

In the cell cycle, the different cyclins show characteristic concentration changes in which temporally defined maxima in cyclin concentration are observed (see Fig. 13.6). The amount of a distinct cyclin available for CDK activation is strictly controlled by the following mechanisms (Fig. 13.7) ... 

The natural products olomoucine 7 and roscovitine 8 are relatively selective kinase inhibitors that bind CDK1, 2, and 5 but have little effect on CDK4 and 6 [18]. These selective CDK inhibitory profiles result in cell cycle arrest in the Gi and G2 phases. Both inhibitors act in a dose-dependent and reversible manner, thus allowing temporal control of CDK activity at different stages of the cell cycle. 

Begasse ML, Hyman AA (2011) The first cell cycle of the Caenorhabditis elegans embryo spatial and temporal control of an asymmetric cell division. Probl Cell Differ 53 109-133. 

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