Sulforaphane cell cycle arrest induced

TULLiEZ J and terce f (2000) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells . Cancer Res, 60 1426-33. 

Matsui TA, Murata H, Sakabe T, Sowa Y, Horie N, Nakanishi R, Sakai T, Kubo T. (2007) Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. Oncol Rep 18 1263-1268. 

Recently, it has been found that, in addition to its detoxification function and its function as a biomarker for up-regulation of other phase II enzymes, up-regulation of quinone reductase by monofunctional inducers may play a role in the stabilization of p53, the protein product of a tumor suppressor gene, which induces growth arrest and apoptosis. Sulforaphane has also been shown to mediate growth arrest and induce cell cycle arrest and apoptosis in many cancer cell lines, including those of human prostate, colon, and T-cell leukemia origin. - The exact mechanisms, and whether all the bioactivities of sulforaphane involve the ARE, are not yet understood. 

Sulforaphane has been shown to induce both apoptosis and cell cycle arrest in several cell lines, including HT29 human colon cancer cells [56], LNCaP human prostate cancer cells [57], and Jurkat human T-leukemia cells [58]. Incubation of such cells with 3-30 pM SF for 24-48 hours resulted in a dose-dependent induction of apoptosis and cell cycle arrest, showing that this compound can induce apoptosis and arrest cell growth and suggesting that this activity is unlikely to be cell type specific. There is also evidence that the concentration of SF required to induce apoptosis and cell cycle arrest may be much... 

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