Cell cycle, in cancer cells

Equally, stabilizing protein-protein interactions has considerable therapeutic potential. For instance, p53 is an important cell cycle protein involved in programmed cell death (apoptosis), which associates to form a tetramer in vivo Furthermore, p53 mutations are commonplace in a wide variety of cancers.Giralt et al. have investigated the development of protein surface recognition sequences that are rich in positively charged residues and bind to anionic domains in monomeric p53 and concluded that such an approach offers considerable potential for targeting the cell cycle in cancerous cells. 

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