Cell cycle, phenolics effect

Curcumin has also been found to interrupt the cell cycle, to have cytotoxic effects, and to have a role in antiproliferation and the induction of apoptosis in a hepatocarcinoma cell line. Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues [Vietri et al., 2003]. Curcumin inhibited the interleukin-6 (IL-6) production, histone acetyltransferase (HAT) activity, and API activation [Chen et al., 2003a] and prevented cell death and apoptotic biochemical changes, such as the... 

Six main common chemopreventive effects that phenolic compounds can exert on cancer cells are (1) antioxidant effect, (2) antiproliferation effect, (3) induction of cell-cycle arrest, (4) induction of apoptosis, (5) antiinflammatory effect, and (6) inhibition of angiogenesis and metastasis (Table 2). 

Janicke B, Hegardt C, Krogh M, et al. The antiproliferative effect of dietary fibre phenolic compounds femlic acid and p-coumaric acid on the cell cycle of Caco-2 cells. Nutr Cancer. 2011 63(4) 611—622. 

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