Cell-cycle-related proteins

The regulation of cell cycle-related proteins by other carotenoids is less investigated. 

Shen KK, Lin TY, Xn C, Ji LL, Wang ZT. (2009) Andrographolide inhibits hepatoma cells growth and affects the expression of cell cycle related proteins. Yao Xue Xue Bao 44 973-979. 

Zaffaroni N, Silvestrini R, Orlandi L, Bearzatto A, Gornati D, Villa R. Induction of apoptosis by taxol and cisplatin and effect on cell cycle-related proteins in cisplatin-sensitive and -resistant human ovarian cells. BrJ Cancer 1998 77(9) 1378-1385. 

Smith MZ, Nagy Z, Esiri MM (1999) Cell cycle-related protein expression in vascular dementia and Alzheimer s disease. Neurosci Lett 271 45 8. 

Chuang, S.E., Cheng, A.L., Lin, J.K., and Kuo, M.L., Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats, Foorf Client. Toxicol, 38 (11) 991-995,2000. 

Bardon S, Foussard V, Foumel S, Loubat A (2002) Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. Cancer Lett 181 187-194... 

Barbieri and coworkers have studied the antiproliferative activity and interactions of cell-cycle-related proteins utilizing the organotin compoimd containing a quinolizidine derivative. The particular compoimd studied was triethyltin lupinylsulfide hydrochloride (5). In early tests this compound was found to show good cancer cell line inhibition, so more extensive studies were undertaken. 

Zhu X, Raina AK, Rottkamp CA, Aliev G, Perry G, Boux H, Smith MA (2001a) Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer s disease. J Neurochem 76 435 41 Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA (2000) Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59 880-888... 

The petroleum ether extract of Panax ginseng has antiproliferative effects on various cancer cell lines (murine sarcoma, murine leukaemia, human colon carcinoma, etc ). Polyacetylenic compounds from this extract such as panaxynol, panaxydol (46) and panaxytriol have been reported to be responsible for these effects [112, 113]. In order to identify the molecular mechanism of the polyacetylene compounds, one of the major cytotoxic compounds, panaxydol, was examined to see if it is able to disrupt cell cycle-related events. It was observed that panaxydol induces cell cycle arrest at Gi-S transition in SK-MEL-1 cells. This effect is related to the decreased Cdk2 activity, which seems to be caused by the increased level of p27 protein expression. The protein synthesis inhibitor cycloheximide reversed the growth suppression induced by panaxydol (80 j,g/ml) by... 

Helps NR, Luo X, Barker HM et al (2000) NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centro-somes, is complexed to protein phosphatase 1. Biochem J 349 509-518... 

Ben-David, Y., Letwin, K., Tannock, L., Bernstein, A., and Pawson, T. (1991). A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 10 317-325. 

Nasmyth The work by Gareth Williams and Ron Laskey with the MCM proteins in cervical cancer is an example of a cell cycle gene that is presumably part of some huge battery of genes that is somehow related to whether the cell is in a proliferative state. It turns out to be rather a good marker for tumour cells. But it is nothing directly to do with proliferation itself. 

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