Cell cycle growth linked

Pattern- and growth-linked cell cycles in Drosophila development... 

Nurse I was specifically trying to link in whether the particular genes concerned with growth and cell cycle had a special significance. 

Eeevers I think it is more likely that there is a link between protein synthesis, growth rate and the production of a specific cell cycle regulator. This is a great mechanism to ensure a minimum cell size, making sure that cells don t divide until they are growing at a certain rate and producing everything they will need to divide at a reasonable level. 

Nickel chloride has been reported to induce DNA strand breaks in CHO cells [435] in a concentration, which did not significantly injure normal cellular division, and DNA-protein cross-links, which were concentration- and time-dependent and preferentially occurred in cells in the late S phase of the cell cycle [436], The nickel cross-linked proteins included nonhistone chromatin proteins, nonhistone DNA-binding proteins and a 30 kDa protein that comigrated electrophoretically with histone HI. Moreover, blocking of cell growth in S phase [249] and induction of DNA repair synthesis in CHO cells [437] and reduction in the fidelity of DNA synthesis [438, 439], have been reported. 

Mechanism of Action An alkylating agent that inhibits DNAand RNA protein synthesis by cross-linking with DNA and RNA strands, preventing cell growth. Cell cycle-phase nonspedflc. Therapeutic Effect Potent immunosuppressant. Pharmacokinetics Well absorbed from the G1 tract. Protein binding low. Crosses the blood-brain barrier. Metabolized in the liver to active metabolites. Primarily excreted in urine. Removed by hemodialysis. Half-life 3-12 hr. 

Multiple links exist between circadian rhythms and cancer. First, the rate of tumor growth in rodents increases as a result of (a) mutations affecting the circadian clock [1] and (b) disruption of the neural pacemaker governing circadian rhythms [2], Second, the cell cycle is directly controlled by the circadian clock [3-5]. This explains why progression through the cell cycle often displays a strong circadian dependence [6-9]. Third, the link between the circadian clock and cancer is further illustrated by the effect of circadian rhythms on a variety of anticancer medica-... 

The phosphorylation of histone H3 can have a repressive or activating effect on transcription. Members of the MAP kinases (see Chapter 10) that are responsible for this phosphorylation have been identified, providing a link between growth factor stimulation and transcription activation at the level of histone modification. H3 phosphorylation has been also recognized as part of a complex signaling mechanism that operates in the condensation/decondensation of chromatin during the cell cycle. Furthermore, histone HI phosphorylation has been linked to the relief of transcription repression. 

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