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Cell cycle mitotic spindle-targeting drugs

Paclitaxel belongs to the family of cytoskeletal drugs which target tubulin. Treatment leads to abnormality of the mitotic spindle assembly, chromosome segregation, and consequently defects of cell division. By stabilizing the microtubule polymer and preventing the disassembly of microtubules, paclitaxel arrests cell cycle in the GO/Gl and G2/M phases and induces apoptosis [134]. [Pg.397]

See other pages where Cell cycle mitotic spindle-targeting drugs is mentioned: [Pg.230]    [Pg.423]    [Pg.92]    [Pg.199]    [Pg.263]    [Pg.436]    [Pg.719]    [Pg.720]    [Pg.247]    [Pg.2960]    [Pg.187]   
See also in sourсe #XX -- [ Pg.441 ]



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Cell cycle

Cell targeting

Drugs targeting

Mitotic

Mitotic cell cycle

Mitotic cycle

Mitotic spindle

Spindles

Target Cell

Targeted drugs

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