Cell cycle checkpoint

Kastan MB, Bartek J (2004) Cell-cycle checkpoints and cancer. Nature 432 316-323... 

Cell Adhesion Molecules Cell-cycle Arrest Cell Cycle Checkpoints Cell Cycle Control Cell Division Cycle Cell Multiplication Cell Proliferation Cellular Immmunity Central Core Disease (CCD)... 

KAUFMANN w K (1998) Human topoisomerase 11 function, tyrosine phosphorylation and cell cycles checkpoints , Proc Soc Exp Biol Med, 217, 327-34. 

Murray, A. W. (1992). Creative blocks cell-cycle checkpoints and feedback controls. Nature 359 599-604. 

DNA damage in the context of the embryo does not inhibit cell division as seen by the synchronous and timely occurrence of cytokinesis. In a similar fashion as a cell cycle checkpoint was uncovered in extracts following inhibition of DNA... 

Elledge SJ 1996 Cell cycle checkpoints preventing an identity crisis. Science 274 1664—1672 Evans EK, Kombluth S 1998 Regulation of apoptosis in Xenopus egg extracts. Adv Enzyme Regul 38 265-280... 

DNA damage-inducible cell cycle checkpoints are complex signal transduction networks that integrate the cellular responses to genotoxic insults by arresting cell cycle... 

Tanaka H, Arakawa H, Yamaguchi T et al. A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage. Nature 404, 42 9, 2000. 

Genetic instability due to breakdown of a repair component is only seen in a small fraction of tumors, however. In the majority of tumors, instabUity at the level of the chromosomes can be established, which is manifested in loss or gain of whole chromosomes or large parts thereof This instability is associated with failure at cell cycle checkpoints (see 13.7,14.4.2). 

It is becoming increasingly obvious that errors in function of cell cycle checkpoints correlate with increased chromosomal instabUity of tumor cells (Lengauer et al., 1998). 

K., Register, J., Margosiak, S., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lund-gren, ., Kan, . C., O Connor, P. M. (2000) The 1.7 A Crystal structure of human cell cycle checkpoint kinase Chkl implications for Chkl regulation. Cell 100, 681-692. 

Li, Q., Zhu, G.D. (2002) Targeting ser-ine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer. Curr Top Med Chem.2, 939-971. 

Collins I, Garrett MD. 2005. Targeting the cell division cycle in cancer CDK and cell cycle checkpoint kinase inhibitors. Curr Opin Pharmacol 5 366-373. 

Bork, P., Hofmann, K., Bucher, P., Neuwald, A., Altschul, S., and Koonin, E. (1997). A superFamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEBJ. 11, 68-76. 

Recently considerable attention has been focused on the metabolites belonging to bisindolylmaleimides such as staurosporine (28) [12], UCN-01 (29) [13], rebeccamycin (30) [14], which were produced by the family of Streptomyces, Actinomycetes, and Saccharothrixes. These metabolites cause topoisomerase I mediated DNA cleavage, potent inhibition of protein kinase C and cell-cycle-regulating cyclin-dependent kinase (CDK), and cell-cycle checkpoint inhibition [15]. It seems interesting that myxomycetes also contain the bisindole metabolites having related structures to 28 - 30. 

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