Cell-cycle-nonspecific cytotoxic agents

Cyclophosphamide is a cytotoxic (cytostatic), cell cycle nonspecific, antiproliferative agent which is used in such diverse medical problems as neoplasia, tissue transplantation and inflammatory diseases. Chemically, it is an inert bioprecursor for a potent nitrogen mustard alkylation agent (Fig. 33.31). 

Thiotepa is an alkylating agent, which is a cell-cycle nonspecific alkylating agent related to nitrogen mustard. Its radiomimetic action is believed to occur through the release of ethylenimine radicals, which disrupt the bonds of DNA. TEPA possesses cytotoxic activity. 

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