Histones synthesis during cell cycle

Pederson, T., and Robbins, E., 1970, Absence of translational control of histone synthesis during the HeLa cell life cycle, J. Cell Biol. 45 509. 

Cell cycle studies of histone phosphorylation using synchronized Chinese hamster ovary cells and HeLa S-3 cells demonstrated that HI and H3 are phosphorylated at different times during the cell cycle, while H2A and H4 are phosphorylated at uniform rates throughout the cell cycle [4—6]. Kinetic studies of the phosphorylation of H2A and H4 in trout testis indicate that these histones are phosphorylated shortly after synthesis [7]. Phosphorylation of H4 did not occur appreciably until after a series of acetylation and deacetylation events, while H2A was phosphorylated shortly after synthesis followed by dephosphorylation. 

Heintz, N., Sive, H. L., and Roeder, R. G., 1983, Regulation of human histone gene expression Kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle. Mol. Cell Biol. 3 539. 

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