Phytochemicals cell cycle modulated

The ability of phytochemicals to modulate cell cycle can be useful in evaluating and optimizing cancer prevention by these compounds. Studies reported here demonstrate that phytochemicals may differentially impact cell cycle and cell number depending upon the mutations in the cancer cell. In addition, cell cycle regulatory proteins are altered by phytochemicals in ways that may explain the cell cycle modulation. The fact that structural features of flavonoids impact cell cycle modulation suggests that cell cycle modulation may be useful in identifying the most active compounds for colon cancer prevention. Finally, cell cycle modulation studies can inform us on plant modifications that may be useful for nutritional enhancement. 

CANCER PREVENTION BY PHYTOCHEMICALS, MODULATION OF CELL CYCLE... 

However, the effect of piperine on SULT and flavonoid status across the life cycle remains to be investigated. Induction of phase II metabolism appears to decrease the bioavailability and accelerate the excretion of flavonoids. For example, Siess et al.115 and Walle et al.116 reported flavones induced rat hepatic UGT activity in HepG2 and Caco-2 cells. This induction of UGT enhanced quercetin glucuronidation in Caco-2 cells. In addition to inducing UGT activity, the flavone chrysin inhibits hepatic SULT-mediated sulfation of acetaminophen and minoxidol." The impact of chrysin on the capacity of COMT action toward flavonoids has not been examined. Further, the effect of age on phase II modulation by piperine and chrysin has not been reported. Thus, information on the relationship between age and intake of flavonoids and other phytochemicals that also affect phase II metabolism is required. 

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