Cell cycle modulators

Two different strategies to control neointimal proliferation after vascular injury are proposed. First is the cytostatic approach, which aims to control the regulation and expression of cell cycle-modulating proteins at any level along the pathway—modulating cell proliferation. Second, the cytotoxic approach—killing proliferating cells—has the... 

The ability of phytochemicals to modulate cell cycle can be useful in evaluating and optimizing cancer prevention by these compounds. Studies reported here demonstrate that phytochemicals may differentially impact cell cycle and cell number depending upon the mutations in the cancer cell. In addition, cell cycle regulatory proteins are altered by phytochemicals in ways that may explain the cell cycle modulation. The fact that structural features of flavonoids impact cell cycle modulation suggests that cell cycle modulation may be useful in identifying the most active compounds for colon cancer prevention. Finally, cell cycle modulation studies can inform us on plant modifications that may be useful for nutritional enhancement. 

Intracellular HA is now well documented, though the functions of this material are unknown [36-39]. It occurs not only in cytoplasm, but also within nuclei and nucleoli. Intracellular HA may function in regulating the cell cycle, modulating the trafficking of specific kinases [40,41] thereby regulating cell behavior. 

The cell cycle-modulated post-transcriptional model shown in Figure 5 is adequate to account for the results described for both synchronized and random populations of mammalian cells in culture. A recent report that actinomycin D stimulated the normally inducible synthesis of tyrosinase in Neurospora crassa (Horowitz et al., 1970) suggests that the type of regulation proposed in Figure 5 may extend to more primitive eukaryotic cells as well. The increasing number of reports that actinomycin D either stimulates the synthesis of certain specific proteins or else prevents their deinduction likewise strongly... 

Streptomyces sp. (CNR-698) Sediment Bahamas (-1618 m) Ammosamides Cell cycle modulators H ughes et o/., 2009a, 2009b Zurwerra, Wullschleger, and Altmann, 2010... 

Hughes, C.C., MacMillan, J.B., Gaudendo, S.P., Jensen, P.R., and Fenical, W. (2009a) The ammosamides structures of cell cycle modulators from a marine-derived Streptomyces species. Angew. Chem. Int. Ed., 48, 725-727. 

Typical dimensions for the /5-alumina electrolyte tube are 380 mm long, with an outer diameter of 28 mm, and a wall thickness of 1.5 mm. A typical battery for automotive power might contain 980 of such cells (20 modules each of 49 cells) and have an open-circuit voltage of lOOV. Capacity exceeds. 50 kWh. The cells operate at an optimum temperature of 300-350°C (to ensure that the sodium polysulfides remain molten and that the /5-alumina solid electrolyte has an adequate Na" " ion conductivity). This means that the cells must be thermally insulated to reduce wasteful loss of heat atjd to maintain the electrodes molten even when not in operation. Such a system is about one-fifth of the weight of an equivalent lead-acid traction battery and has a similar life ( 1000 cycles). 

The ankyrin repeat motif is one of the most common protein-protein interaction domains. Ankyrin repeats are modules of about 33 amino acids repeated in tandem. They are found in a large number of proteins with diverse cellular functions such as transcriptional regulators, signal transducers, cell-cycle regulators, and cytoskeletal proteins. 

Antoch M, Kondratov R, Takahashi J (2005) Circadian clock genes as modulators of sensitivity to genotoxic stress. Cell Cycle 4901-907... 

Modulation of Neuronal Cell Cycle Proteins by Chemokine Receptors and Its Role in the Survival of Postmitotic Neurons... 

Modulation of Neuronal Cell Cycle Proteins by Chemokine Receptors... 

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