Cell-cycle inhibition

Natural products containing a spiropyrrolidinyloxindole nucleus have recently found to exhibit interesting biological activity such as cell-cycle inhibition [23]. This observation encouraged Murphy and coworkers to design a novel domino route to ( )-horsfiline (3-43), a natural spiropyrrolidinyloxindole (Scheme 3.13) [24]. Treatment of azide 3-39 with tris(trimethylsilyl)silane (TTMSS) and AIBN as radical starter led to the radical intermediate 3-40 after a first ring closure, which under-... 

Wilmer, J.L., A.D.Kligerman, and G.L.Erexson. 1981. Sister chromatid exchange induction and cell cycle inhibition by aniline and its metabolites in human fibroblasts. Environ. Mutagen. 3 627-638. 

Cytoskeleton injury blebbing, shrinkage in apoptosis increased size in mitosis nuclear size contraction with apoptosis and swelling with cell cycle inhibition... 

Luo, Y, Hurwitz, J. and Massague, J. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21 (1995) Nature 275,159-161... 

Mann, M.J., Gibbons, G.H., Tsao, P.S., vonderLeyen, H.E., Cooke, J.P., Buitrago, R. etal. (1997) Cell cycle inhibition preserves endothelial function in genetically engineered rabbit vein grafts. J. Clin. Invest., 99, 1295-1301. 

Dihydroarcyriarubin C (104), a new bisindole alkaloid, has been isolated from fruit bodies of a myxomycete Arcyria ferruginea, which was collected at Hao, Yasu-cho, Kochi Prefecture, together with two known bisindoles, arcyriarubin C (2) and arcyriaflavin C (4), and the structure of 104 was elucidated by spectral data. Arcyriaflavin C (4) was also obtained, together with arcyriaflavin B (3), from fruit bodies of Tub if era casparyi, which ( 16839) was collected at Mt. Miune, Monobe-mura, Kochi Prefecture, in November 1997. Arcyriaflavin C (4) was revealed to exhibit cell cycle inhibition activity on HeLa cells on the basis of flow cytometry studies. Fruit bodies of Fuligo Candida, which ( 23446) was collected at Motoyama-cho, Kochi Prefecture, in August 2002, were revealed to contain a relatively high quantity of cycloanthranilylproline (105). 

Flavone (= 2-Phenyl-1,4- Ammi visnaga, Anethum graveolens diuretic, hypotensive cell cycle inhibition (at 20-40)] ARH-R (AD-R, COX, 5-LOX... 

Galangin (= 3,5,7- Pimelea decora, P. simplex (Thymelaeaceae) Escallonia spp. (Saxifrageaceae) release cell cycle inhibition (at 20-50)] ARH-R (blocks activation) [apoptotic]... 

Guckert, J.B. and Cooksey, K.E. (1990) Triglyceride accumulation and fatty acid profile changes in Chlorella (Chlorophyta) during high pH-induced cell cycle inhibition. J. Phycol. 26, 72-79. 

Cell cycle inhibition by allylsulfides. Knowles and Milner (1998) demonstrated the cell cycle arrest in the DADS-treated HCT-15 cells. DADS decreased the proportion of cells in the G1 phase and, in turn, increased the proportion of cells in the G2/M phase. Refeeding of DADS-treated cells with a complete medium without DADS restored their normal proliferation rates. Consistent with the G2/M phase arrest, DADS inhibited p34 2 kinase activity. The maximum depression in p34 kinase activity (53%) was observed in the culture with 25 pM DADS. 

Di Giovanni, S., Movsesyan, V, Ahmed, E, et al., 2005. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc. Natl. Acad. Sci. USA 102, 8333-8338. Dohi, K., Satoh, K., Mihara, Y, et al., 2006. Alkoxyl radical-scavenging activity of edaravone in patients with traumatic brain injury. J. Neurotrauma 23, 1591-1599. 

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